Remotely Monitored Cardiac Implantable Electronic Device Data Predict All‐Cause and Cardiovascular Unplanned Hospitalization

Camilla Sammut‐Powell, Joanne Taylor, Manish Motwani, Catherine M. Leonard, Glen Martin, fozia ahmed

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Unplanned hospitalizations are common in patients with cardiovascular disease. The “Triage Heart Failure Risk Status” (Triage-HFRS) algorithm in patients with cardiac implantable electronic devices uses data from up to 9 device-derived physiological parameters to stratify patients as low/medium/high risk of 30-day heart failure (HF) hospitalization, but its use to predict all-cause hospitalization has not been explored. We examined the association between Triage-HFRS and risk of all-cause, cardiovascular, or HF hospitalization. METHODS AND RESULTS: A prospective observational study of 435 adults (including patients with and without HF) with a Medtronic Triage-HFRS–enabled cardiac implantable electronic device (cardiac resynchronization therapy device, implant-able cardioverter-defibrillator, or pacemaker). Cox proportional hazards models explored association between Triage-HFRS and time to hospitalization; a frailty term at the patient level accounted for repeated measures. A total of 274 of 435 patients (63.0%) transmitted ≥1 high HFRS transmission before or during the study period. The remaining 161 patients never transmitted a high HFRS. A total of 153 (32.9%) patients had ≥1 unplanned hospitalization during the study period, totaling 356 nonelective hospitalizations. A high HFRS conferred a 37.3% sensitivity and an 86.2% specificity for 30-day all-cause hospitalization; and for HF hospitalizations, these numbers were 62.5% and 85.6%, respectively. Compared with a low Triage-HFRS, a high HFRS conferred a 4.2 relative risk of 30-day all-cause hospitalization (8.5% versus 2.0%), a 5.0 relative risk of 30-day cardiovascular hospitalization (3.6% versus 0.7%), and a 7.7 relative risk of 30-day HF hospitalization (2.0% versus 0.3%). CONCLUSIONS: In patients with cardiac implantable electronic devices, remotely monitored Triage-HFRS data discriminated between patients at high and low risk of all-cause hospitalization (cardiovascular or noncardiovascular) in real time.

Original languageEnglish
Article numbere024526
JournalJournal of the American Heart Association
Issue number16
Publication statusPublished - 9 Aug 2022


  • all-cause hospitalization
  • cardiac-resynchronization therapy
  • cardiovascular hospitalization
  • heart failure
  • implantable cardioverter defibrillators
  • remote monitoring
  • risk prediction


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