Abstract
The effects of a mixed pressor and anti-diuretic vasopressin antagonist on blood pressure and renal function have been investigated in New Zealand genetically hypertensive and normotensive rats. Vasopressin antagonism was associated with a diuresis, compensatory polydipsia and kaliuresis in both normotensive and hypertensive animals. Hypertensive animals alone exhibited a natriuresis and a fall in systolic blood pressure, which was associated with a reduction in water balance and plasma sodium compared with antagonist-treated normotensive animals. The data suggest that vasopressin may exert a long-term influence on blood pressure through renally rather than vascularly mediated effects.
| Original language | English |
|---|---|
| Pages (from-to) | 591-597 |
| Number of pages | 6 |
| Journal | Acta Endocrinologica |
| Volume | 120 |
| Issue number | 5 |
| Publication status | Published - 1989 |