Renal and blood pressure changes in response to vasopressin antagonism in the New Zealand genetically hypertensive rat

N. Ashton, R. J. Balment

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The effects of a mixed pressor and anti-diuretic vasopressin antagonist on blood pressure and renal function have been investigated in New Zealand genetically hypertensive and normotensive rats. Vasopressin antagonism was associated with a diuresis, compensatory polydipsia and kaliuresis in both normotensive and hypertensive animals. Hypertensive animals alone exhibited a natriuresis and a fall in systolic blood pressure, which was associated with a reduction in water balance and plasma sodium compared with antagonist-treated normotensive animals. The data suggest that vasopressin may exert a long-term influence on blood pressure through renally rather than vascularly mediated effects.
    Original languageEnglish
    Pages (from-to)591-597
    Number of pages6
    JournalActa Endocrinologica
    Volume120
    Issue number5
    Publication statusPublished - 1989

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