Renal haemodynamic and tubular actions of urotensin II in the rat

Alaa E S Abdel-Razik; Ellen J. Forty; Richard J. Balment; Nick Ashton

doi:10.1677/JOE-08-0260

Renal haemodynamic and tubular actions of urotensin II in the rat

Alaa E S Abdel-Razik, Ellen J. Forty, Richard J. Balment, Nick Ashton

Research output: Contribution to journal › Article › peer-review

Abstract

Urotensin II (UTS) is a potent vasoactive peptide that was originally identified in teleost fish. Mammalian orthologues of UTS and its receptor (UTSR) have been described in several species, including humans and rats. We have shown previously that bolus injections of UTS caused a decrease in urine flow and sodium excretion rates in parallel with marked reductions in renal blood flow (RBF) and glomerular filtration rate (GFR). The aim of this study was to determine the effect of UTS infusion at a dose that has minimal impact upon renal haemodynamics in order to identify a potential direct tubular action of UTS. Infusion of rat UTS (rUTS) at 0.6 pmol/min per 100 g body weight in male Sprague-Dawley rats, which had no effect on RBF and caused a 30% reduction in GFR, resulted in a significant increase in the fractional excretion of sodium (vehicle 2.3±0.6 versus rUTS 0.6 pmol 4.5±0.6%, P

Original language	English
Pages (from-to)	617-624
Number of pages	7
Journal	Journal of Endocrinology
Volume	198
Issue number	3
DOIs	https://doi.org/10.1677/JOE-08-0260
Publication status	Published - Sept 2008

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title = "Renal haemodynamic and tubular actions of urotensin II in the rat",

abstract = "Urotensin II (UTS) is a potent vasoactive peptide that was originally identified in teleost fish. Mammalian orthologues of UTS and its receptor (UTSR) have been described in several species, including humans and rats. We have shown previously that bolus injections of UTS caused a decrease in urine flow and sodium excretion rates in parallel with marked reductions in renal blood flow (RBF) and glomerular filtration rate (GFR). The aim of this study was to determine the effect of UTS infusion at a dose that has minimal impact upon renal haemodynamics in order to identify a potential direct tubular action of UTS. Infusion of rat UTS (rUTS) at 0.6 pmol/min per 100 g body weight in male Sprague-Dawley rats, which had no effect on RBF and caused a 30% reduction in GFR, resulted in a significant increase in the fractional excretion of sodium (vehicle 2.3±0.6 versus rUTS 0.6 pmol 4.5±0.6%, P",

author = "Abdel-Razik, {Alaa E S} and Forty, {Ellen J.} and Balment, {Richard J.} and Nick Ashton",

year = "2008",

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doi = "10.1677/JOE-08-0260",

language = "English",

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TY - JOUR

T1 - Renal haemodynamic and tubular actions of urotensin II in the rat

AU - Abdel-Razik, Alaa E S

AU - Forty, Ellen J.

AU - Balment, Richard J.

AU - Ashton, Nick

PY - 2008/9

Y1 - 2008/9

N2 - Urotensin II (UTS) is a potent vasoactive peptide that was originally identified in teleost fish. Mammalian orthologues of UTS and its receptor (UTSR) have been described in several species, including humans and rats. We have shown previously that bolus injections of UTS caused a decrease in urine flow and sodium excretion rates in parallel with marked reductions in renal blood flow (RBF) and glomerular filtration rate (GFR). The aim of this study was to determine the effect of UTS infusion at a dose that has minimal impact upon renal haemodynamics in order to identify a potential direct tubular action of UTS. Infusion of rat UTS (rUTS) at 0.6 pmol/min per 100 g body weight in male Sprague-Dawley rats, which had no effect on RBF and caused a 30% reduction in GFR, resulted in a significant increase in the fractional excretion of sodium (vehicle 2.3±0.6 versus rUTS 0.6 pmol 4.5±0.6%, P

AB - Urotensin II (UTS) is a potent vasoactive peptide that was originally identified in teleost fish. Mammalian orthologues of UTS and its receptor (UTSR) have been described in several species, including humans and rats. We have shown previously that bolus injections of UTS caused a decrease in urine flow and sodium excretion rates in parallel with marked reductions in renal blood flow (RBF) and glomerular filtration rate (GFR). The aim of this study was to determine the effect of UTS infusion at a dose that has minimal impact upon renal haemodynamics in order to identify a potential direct tubular action of UTS. Infusion of rat UTS (rUTS) at 0.6 pmol/min per 100 g body weight in male Sprague-Dawley rats, which had no effect on RBF and caused a 30% reduction in GFR, resulted in a significant increase in the fractional excretion of sodium (vehicle 2.3±0.6 versus rUTS 0.6 pmol 4.5±0.6%, P

U2 - 10.1677/JOE-08-0260

DO - 10.1677/JOE-08-0260

M3 - Article

SN - 1479-6805

VL - 198

SP - 617

EP - 624

JO - Journal of Endocrinology

JF - Journal of Endocrinology

IS - 3

ER -

Renal haemodynamic and tubular actions of urotensin II in the rat

Abstract

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