Renal physiology of the extracellular calcium-sensing receptor.

DT Ward; D Riccardi

doi:10.1007/s00424-002-0914-x

Renal physiology of the extracellular calcium-sensing receptor.

DT Ward, D Riccardi

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

The kidney is a fundamental component of the Ca²⁺ homeostatic system and its ability to sense extracellular Ca²⁺ ([Ca²⁺]_o) levels in the urinary filtrate and the interstitial fluid is an important ionic feedback mechanism in achieving normocalcaemia. The protein responsible for the measurement of [Ca²⁺]_o is the extracellular Ca²⁺-sensing receptor (CaR), which is expressed in multiple sites along the nephron. Its cellular localization and apparent function(s) appear to depend upon the region of the nephron in which it is expressed. The renal expression of CaR will be detailed in this review and its role in integrating [Ca²⁺]_o with the calciotropic signals responsible for Ca²⁺ homeostasis will be discussed.

Original language	English
Pages (from-to)	169–176
Number of pages	8
Journal	Pflügers Archiv European Journal of Physiology
Volume	445
Issue number	2
DOIs	https://doi.org/10.1007/s00424-002-0914-x
Publication status	Published - Nov 2002

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10.1007/s00424-002-0914-x

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title = "Renal physiology of the extracellular calcium-sensing receptor.",

abstract = "The kidney is a fundamental component of the Ca2+ homeostatic system and its ability to sense extracellular Ca2+ ([Ca2+]o) levels in the urinary filtrate and the interstitial fluid is an important ionic feedback mechanism in achieving normocalcaemia. The protein responsible for the measurement of [Ca2+]o is the extracellular Ca2+-sensing receptor (CaR), which is expressed in multiple sites along the nephron. Its cellular localization and apparent function(s) appear to depend upon the region of the nephron in which it is expressed. The renal expression of CaR will be detailed in this review and its role in integrating [Ca2+]o with the calciotropic signals responsible for Ca2+ homeostasis will be discussed.",

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AB - The kidney is a fundamental component of the Ca2+ homeostatic system and its ability to sense extracellular Ca2+ ([Ca2+]o) levels in the urinary filtrate and the interstitial fluid is an important ionic feedback mechanism in achieving normocalcaemia. The protein responsible for the measurement of [Ca2+]o is the extracellular Ca2+-sensing receptor (CaR), which is expressed in multiple sites along the nephron. Its cellular localization and apparent function(s) appear to depend upon the region of the nephron in which it is expressed. The renal expression of CaR will be detailed in this review and its role in integrating [Ca2+]o with the calciotropic signals responsible for Ca2+ homeostasis will be discussed.

UR - http://europepmc.org/abstract/med/12457237

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DO - 10.1007/s00424-002-0914-x

M3 - Review article

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EP - 176

JO - Pflügers Archiv European Journal of Physiology

JF - Pflügers Archiv European Journal of Physiology

IS - 2

ER -

Renal physiology of the extracellular calcium-sensing receptor.

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