Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups

Kevin J. Fettes; Nigel Howard; David T. Hickman; Steven A. Adah; Mark R. Player; Paul F. Torrence; Jason Micklefield

Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups

Kevin J. Fettes, Nigel Howard, David T. Hickman, Steven A. Adah, Mark R. Player, Paul F. Torrence, Jason Micklefield

Research output: Contribution to journal › Article › peer-review

Abstract

Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.

Original language	English
Pages (from-to)	765-766
Number of pages	1
Journal	Chemical Communications
Issue number	9
Publication status	Published - 7 May 2000

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@article{7955b882db2e40108244577b31668961,

title = "Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups",

abstract = "Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.",

author = "Fettes, {Kevin J.} and Nigel Howard and Hickman, {David T.} and Adah, {Steven A.} and Player, {Mark R.} and Torrence, {Paul F.} and Jason Micklefield",

year = "2000",

month = may,

day = "7",

language = "English",

pages = "765--766",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "9",

}

TY - JOUR

T1 - Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups

AU - Fettes, Kevin J.

AU - Howard, Nigel

AU - Hickman, David T.

AU - Adah, Steven A.

AU - Player, Mark R.

AU - Torrence, Paul F.

AU - Micklefield, Jason

PY - 2000/5/7

Y1 - 2000/5/7

N2 - Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.

AB - Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.

M3 - Article

SN - 1359-7345

SP - 765

EP - 766

JO - Chemical Communications

JF - Chemical Communications

IS - 9

ER -

Replacement of the phosphodiester linkage in dna with sulfamide and 3'- N-sulfamate groups

Abstract

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