Solid tumors are under-sampled in the clinic, such that only 0.0005% of initial tumor volume is used as input for diagnostic testing. Litchfield et al. apply the principles of representative sampling to implement an unbiased tumor sampling approach that improves the reproducibility and accuracy of next-generation sequencing.

Original languageEnglish
Article number107550
Pages (from-to)107550
JournalCell Reports
Issue number5
Publication statusPublished - 5 May 2020


  • biomarkers
  • homogenization
  • molecular profiling
  • representative sampling
  • tumor hetereogeneity
  • tumor mutational burden
  • tumor sampling
  • tumor sequencing

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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