Requirement of the JIP1 scaffold protein for stress-induced JNK activation

A. J. Whitmarsh, C. Y. Kuan, N. J. Kennedy, N. Kelkar, T. F. Haydar, J. P. Mordes, M. Appel, A. A. Rossini, S. N. Jones, R. A. Flavell, P. Rakic, R. J. Davis

    Research output: Contribution to journalArticlepeer-review


    The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.
    Original languageEnglish
    Pages (from-to)2421-2432
    Number of pages11
    JournalGenes and development
    Issue number18
    Publication statusPublished - 15 Sept 2001


    • JIP1
    • JNK
    • MAP kinase
    • Scaffold


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