Requirement of the JIP1 scaffold protein for stress-induced JNK activation

A. J. Whitmarsh; C. Y. Kuan; N. J. Kennedy; N. Kelkar; T. F. Haydar; J. P. Mordes; M. Appel; A. A. Rossini; S. N. Jones; R. A. Flavell; P. Rakic; R. J. Davis

doi:10.1101/gad.922801

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

A. J. Whitmarsh, C. Y. Kuan, N. J. Kennedy, N. Kelkar, T. F. Haydar, J. P. Mordes, M. Appel, A. A. Rossini, S. N. Jones, R. A. Flavell, P. Rakic, R. J. Davis

Research output: Contribution to journal › Article › peer-review

Abstract

The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.

Original language	English
Pages (from-to)	2421-2432
Number of pages	11
Journal	Genes and development
Volume	15
Issue number	18
DOIs	https://doi.org/10.1101/gad.922801
Publication status	Published - 15 Sept 2001

Keywords

JIP1
JNK
MAP kinase
Scaffold

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10.1101/gad.922801

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title = "Requirement of the JIP1 scaffold protein for stress-induced JNK activation",

abstract = "The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.",

keywords = "JIP1, JNK, MAP kinase, Scaffold",

author = "Whitmarsh, {A. J.} and Kuan, {C. Y.} and Kennedy, {N. J.} and N. Kelkar and Haydar, {T. F.} and Mordes, {J. P.} and M. Appel and Rossini, {A. A.} and Jones, {S. N.} and Flavell, {R. A.} and P. Rakic and Davis, {R. J.}",

year = "2001",

month = sep,

day = "15",

doi = "10.1101/gad.922801",

language = "English",

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pages = "2421--2432",

journal = "Genes and development",

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TY - JOUR

T1 - Requirement of the JIP1 scaffold protein for stress-induced JNK activation

AU - Whitmarsh, A. J.

AU - Kuan, C. Y.

AU - Kennedy, N. J.

AU - Kelkar, N.

AU - Haydar, T. F.

AU - Mordes, J. P.

AU - Appel, M.

AU - Rossini, A. A.

AU - Jones, S. N.

AU - Flavell, R. A.

AU - Rakic, P.

AU - Davis, R. J.

PY - 2001/9/15

Y1 - 2001/9/15

N2 - The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.

AB - The c-Jun N-terminal kinase (JNK) signal transduction pathway is activated in response to the exposure of cells to environmental stress. Components of the JNK signaling pathway interact with the JIP1 scaffold protein. JIP1 is located in the neurites of primary hippocampal neurons. However, in response to stress, JIP1 accumulates in the soma together with activated JNK and phosphorylated c-Jun. Disruption of the Jip1 gene in mice by homologous recombination prevented JNK activation caused by exposure to excitotoxic stress and anoxic stress in vivo and in vitro. These data show that the JIP1 scaffold protein is a critical component of a MAP-kinase signal transduction pathway.

KW - JIP1

KW - JNK

KW - MAP kinase

KW - Scaffold

U2 - 10.1101/gad.922801

DO - 10.1101/gad.922801

M3 - Article

C2 - 11562351

SN - 0890-9369

VL - 15

SP - 2421

EP - 2432

JO - Genes and development

JF - Genes and development

IS - 18

ER -

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

Abstract

Keywords

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