Rescuing microtubules from the brink of catastrophe: CLASPs lead the way

Elizabeth Lawrence; Marija Zanic

doi:10.1016/j.ceb.2018.10.011

Rescuing microtubules from the brink of catastrophe: CLASPs lead the way

Elizabeth Lawrence, Marija Zanic^*

^*Corresponding author for this work

Division of Molecular & Cellular Function (L5)

Vanderbilt University

Research output: Contribution to journal › Article › peer-review

Abstract

Microtubules are cytoskeletal polymers that dynamically remodel to perform essential cellular functions. Individual microtubules alternate between phases of growth and shrinkage via sudden transitions called catastrophe and rescue, driven by losing and regaining a stabilizing cap at the dynamic microtubule end. New in vitro studies now show that a conserved family of CLASP proteins specifically modulate microtubule catastrophe and rescue transitions. Further, recent cryo-electron microscopy approaches have elucidated new structural features of the stabilizing cap. Together, these new advances provide a clearer view on the complexity of the microtubule end and its regulation.

Original language	English
Journal	Current opinion in cell biology
DOIs	https://doi.org/10.1016/j.ceb.2018.10.011
Publication status	Published - 1 Feb 2019

Keywords

Microtubules
Microtubule associated protein
Microtubule catastrophe
Microtubule rescue
CLASPs

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10.1016/j.ceb.2018.10.011

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title = "Rescuing microtubules from the brink of catastrophe: CLASPs lead the way",

abstract = "Microtubules are cytoskeletal polymers that dynamically remodel to perform essential cellular functions. Individual microtubules alternate between phases of growth and shrinkage via sudden transitions called catastrophe and rescue, driven by losing and regaining a stabilizing cap at the dynamic microtubule end. New in vitro studies now show that a conserved family of CLASP proteins specifically modulate microtubule catastrophe and rescue transitions. Further, recent cryo-electron microscopy approaches have elucidated new structural features of the stabilizing cap. Together, these new advances provide a clearer view on the complexity of the microtubule end and its regulation.",

keywords = "Microtubules, Microtubule associated protein, Microtubule catastrophe, Microtubule rescue, CLASPs",

author = "Elizabeth Lawrence and Marija Zanic",

year = "2019",

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AU - Lawrence, Elizabeth

AU - Zanic, Marija

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N2 - Microtubules are cytoskeletal polymers that dynamically remodel to perform essential cellular functions. Individual microtubules alternate between phases of growth and shrinkage via sudden transitions called catastrophe and rescue, driven by losing and regaining a stabilizing cap at the dynamic microtubule end. New in vitro studies now show that a conserved family of CLASP proteins specifically modulate microtubule catastrophe and rescue transitions. Further, recent cryo-electron microscopy approaches have elucidated new structural features of the stabilizing cap. Together, these new advances provide a clearer view on the complexity of the microtubule end and its regulation.

AB - Microtubules are cytoskeletal polymers that dynamically remodel to perform essential cellular functions. Individual microtubules alternate between phases of growth and shrinkage via sudden transitions called catastrophe and rescue, driven by losing and regaining a stabilizing cap at the dynamic microtubule end. New in vitro studies now show that a conserved family of CLASP proteins specifically modulate microtubule catastrophe and rescue transitions. Further, recent cryo-electron microscopy approaches have elucidated new structural features of the stabilizing cap. Together, these new advances provide a clearer view on the complexity of the microtubule end and its regulation.

KW - Microtubules

KW - Microtubule associated protein

KW - Microtubule catastrophe

KW - Microtubule rescue

KW - CLASPs

UR - http://dx.doi.org/10.1016/j.ceb.2018.10.011

U2 - 10.1016/j.ceb.2018.10.011

DO - 10.1016/j.ceb.2018.10.011

M3 - Article

SN - 0955-0674

JO - Current opinion in cell biology

JF - Current opinion in cell biology

ER -

Rescuing microtubules from the brink of catastrophe: CLASPs lead the way

Abstract

Keywords

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