(Re)solution of a protein fold without solution

Perdita E. Barran

doi:DOI 10.1002/anie.201007231

(Re)solution of a protein fold without solution

Research output: Contribution to journal › Article › peer-review

Abstract

Who needs water? The gas phase may seem an esoteric place to examine the structures of proteins, but a new study reveals that the solution fold of the protein KIX can be retained for significant time periods in a mass spectrometer. Once in this ideal laboratory environment, details of the higher order fold can be elucidated at the single amino acid level. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	3120-3122
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	14
DOIs	https://doi.org/DOI 10.1002/anie.201007231
Publication status	Published - 28 Mar 2011

Keywords

gas-phase conformations
mass spectrometry
protein structures
structure elucidation

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DOI 10.1002/anie.201007231

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title = "(Re)solution of a protein fold without solution",

abstract = "Who needs water? The gas phase may seem an esoteric place to examine the structures of proteins, but a new study reveals that the solution fold of the protein KIX can be retained for significant time periods in a mass spectrometer. Once in this ideal laboratory environment, details of the higher order fold can be elucidated at the single amino acid level. Copyright {\textcopyright} 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "gas-phase conformations, mass spectrometry, protein structures, structure elucidation",

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year = "2011",

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N2 - Who needs water? The gas phase may seem an esoteric place to examine the structures of proteins, but a new study reveals that the solution fold of the protein KIX can be retained for significant time periods in a mass spectrometer. Once in this ideal laboratory environment, details of the higher order fold can be elucidated at the single amino acid level. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - Who needs water? The gas phase may seem an esoteric place to examine the structures of proteins, but a new study reveals that the solution fold of the protein KIX can be retained for significant time periods in a mass spectrometer. Once in this ideal laboratory environment, details of the higher order fold can be elucidated at the single amino acid level. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - gas-phase conformations

KW - mass spectrometry

KW - protein structures

KW - structure elucidation

U2 - DOI 10.1002/anie.201007231

DO - DOI 10.1002/anie.201007231

M3 - Article

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VL - 50

SP - 3120

EP - 3122

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

(Re)solution of a protein fold without solution

Abstract

Keywords

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