Resolving the dark side of therapy-driven cancer cell death

Eduardo Bonavita; Victoria S Pelly; Santiago Zelenay

doi:10.1084/jem.20172044

Resolving the dark side of therapy-driven cancer cell death

Eduardo Bonavita, Victoria S Pelly, Santiago Zelenay

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article

Abstract

In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.

Original language	English
Pages (from-to)	9-11
Number of pages	3
Journal	The Journal of experimental medicine
Volume	215
Issue number	1
DOIs	https://doi.org/10.1084/jem.20172044
Publication status	Published - 2 Jan 2018

Keywords

Cell Count
Cell Death
Fatty Acids
Humans
Inflammation
Neoplasms

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1084/jem.20172044

Cite this

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title = "Resolving the dark side of therapy-driven cancer cell death",

abstract = "In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.",

keywords = "Cell Count, Cell Death, Fatty Acids, Humans, Inflammation, Neoplasms",

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AU - Pelly, Victoria S

AU - Zelenay, Santiago

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AB - In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.

KW - Cell Count

KW - Cell Death

KW - Fatty Acids

KW - Humans

KW - Inflammation

KW - Neoplasms

U2 - 10.1084/jem.20172044

DO - 10.1084/jem.20172044

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Resolving the dark side of therapy-driven cancer cell death

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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