Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

D E Nelson, C A Horton, V See, J R Johnson, G Nelson, D G Spiller, D B Kell, M R H White

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.
    Original languageEnglish
    JournalScience
    Volume308
    Issue number5718
    DOIs
    Publication statusPublished - 2005

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