Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

D E Nelson; C A Horton; V See; J R Johnson; G Nelson; D G Spiller; D B Kell; M R H White

doi:10.1126/science.1108198

Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

D E Nelson, C A Horton, V See, J R Johnson, G Nelson, D G Spiller, D B Kell, M R H White

Research output: Contribution to journal › Article › peer-review

Abstract

Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

Original language	English
Journal	Science
Volume	308
Issue number	5718
DOIs	https://doi.org/10.1126/science.1108198
Publication status	Published - 2005

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10.1126/science.1108198

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title = "Response to Comment on {"}Oscillations in NF-kappa B signaling control the dynamics of gene expression{"}",

abstract = "Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.",

author = "Nelson, {D E} and Horton, {C A} and V See and Johnson, {J R} and G Nelson and Spiller, {D G} and Kell, {D B} and White, {M R H}",

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doi = "10.1126/science.1108198",

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journal = "Science",

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T1 - Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

AU - Nelson, D E

AU - Horton, C A

AU - See, V

AU - Johnson, J R

AU - Nelson, G

AU - Spiller, D G

AU - Kell, D B

AU - White, M R H

PY - 2005

Y1 - 2005

N2 - Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

AB - Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

U2 - 10.1126/science.1108198

DO - 10.1126/science.1108198

M3 - Article

VL - 308

JO - Science

JF - Science

SN - 0036-8075

IS - 5718

ER -

Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

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