Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product

A K Langton; J C Mcconnell; L F Cotterell; P Halai; T W Griffiths; C E M Griffiths; R E B Watson

doi:10.1111/jdv.17612

Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product

A K Langton, J C Mcconnell, L F Cotterell, P Halai, T W Griffiths, C E M Griffiths, R E B Watson

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Abstract

Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) [3]. The ‘Manchester Patch-Test’ (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products [4].

Original language	English
Journal	Journal of the European Academy of Dermatology and Venereology
Early online date	20 Aug 2021
DOIs	https://doi.org/10.1111/jdv.17612
Publication status	E-pub ahead of print - 20 Aug 2021

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(21 08 06) AKL CG Skin JEADVAccepted author manuscript, 502 KB

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Langton, A. K., Mcconnell, J. C., Cotterell, L. F., Halai, P., Griffiths, T. W., Griffiths, C. E. M., & Watson, R. E. B. (2021). Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product. Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.17612

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abstract = "Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) [3]. The {\textquoteleft}Manchester Patch-Test{\textquoteright} (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products [4].",

author = "Langton, {A K} and Mcconnell, {J C} and Cotterell, {L F} and P Halai and Griffiths, {T W} and Griffiths, {C E M} and Watson, {R E B}",

year = "2021",

month = aug,

day = "20",

doi = "10.1111/jdv.17612",

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T1 - Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product

AU - Langton, A K

AU - Mcconnell, J C

AU - Cotterell, L F

AU - Halai, P

AU - Griffiths, T W

AU - Griffiths, C E M

AU - Watson, R E B

PY - 2021/8/20

Y1 - 2021/8/20

N2 - Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) [3]. The ‘Manchester Patch-Test’ (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products [4].

AB - Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) [3]. The ‘Manchester Patch-Test’ (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products [4].

U2 - 10.1111/jdv.17612

DO - 10.1111/jdv.17612

M3 - Letter

JO - European Academy of Dermatology and Venereology. Journal

JF - European Academy of Dermatology and Venereology. Journal

SN - 0926-9959

ER -

Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product

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