Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM)  and fibrillar collagen . The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) . The ‘Manchester Patch-Test’ (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products .
|Journal||Journal of the European Academy of Dermatology and Venereology|
|Early online date||20 Aug 2021|
|Publication status||E-pub ahead of print - 20 Aug 2021|