Retinoblastoma in Great Britain 1963-2002

A. MacCarthy; J. M. Birch; G. J. Draper; J. L. Hungerford; J. E. Kingston; M. E. Kroll; Z. Onadim; C. A. Stiller; T. J. Vincent; M. F G Murphy

doi:10.1136/bjo.2008.139618

Retinoblastoma in Great Britain 1963-2002

A. MacCarthy, J. M. Birch, G. J. Draper, J. L. Hungerford, J. E. Kingston, M. E. Kroll, Z. Onadim, C. A. Stiller, T. J. Vincent, M. F G Murphy

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: This paper describes the epidemiology and family history status of 1601 children with retinoblastoma in Great Britain diagnosed 1963-2002 and summarises the practical consequences for diagnosis and counselling of developments in molecular genetics. Methods: Incidence rates were analysed according to year of diagnosis and tumour laterality. Cases were classified as heritable or non-heritable on the basis of laterality and family history of the disease. Results: There were 998 unilateral cases, 581 bilateral and 22 of unknown laterality. Bilateral cases tended to be diagnosed at a younger age than unilateral. All bilateral cases are regarded as heritable, and 35% had a family history of the disease. 7% of the unilateral cases had a family history and are therefore heritable. Thus, at least (41%) of our cases are heritable. This is an underestimate, since these data on family history are incomplete. For unilateral cases aged below 1 year, the reported incidence rate increased significantly (p

Original language	English
Pages (from-to)	33-37
Number of pages	4
Journal	British Journal Of Ophthalmology
Volume	93
Issue number	1
DOIs	https://doi.org/10.1136/bjo.2008.139618
Publication status	Published - Jan 2009

Keywords

Adolescent
Age Distribution
Child
Child, Preschool
Female
Genetic Counseling
Great Britain/epidemiology
Humans
Infant
Infant, Newborn
Male
Registries/statistics & numerical data
Retinal Neoplasms/ epidemiology/pathology
Retinoblastoma/ epidemiology/pathology
Sex Distribution
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/bjo.2008.139618

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title = "Retinoblastoma in Great Britain 1963-2002",

abstract = "Aim: This paper describes the epidemiology and family history status of 1601 children with retinoblastoma in Great Britain diagnosed 1963-2002 and summarises the practical consequences for diagnosis and counselling of developments in molecular genetics. Methods: Incidence rates were analysed according to year of diagnosis and tumour laterality. Cases were classified as heritable or non-heritable on the basis of laterality and family history of the disease. Results: There were 998 unilateral cases, 581 bilateral and 22 of unknown laterality. Bilateral cases tended to be diagnosed at a younger age than unilateral. All bilateral cases are regarded as heritable, and 35% had a family history of the disease. 7% of the unilateral cases had a family history and are therefore heritable. Thus, at least (41%) of our cases are heritable. This is an underestimate, since these data on family history are incomplete. For unilateral cases aged below 1 year, the reported incidence rate increased significantly (p",

keywords = "Adolescent, Age Distribution, Child, Child, Preschool, Female, Genetic Counseling, Great Britain/epidemiology, Humans, Infant, Infant, Newborn, Male, Registries/statistics & numerical data, Retinal Neoplasms/ epidemiology/pathology, Retinoblastoma/ epidemiology/pathology, Sex Distribution, Time Factors",

author = "A. MacCarthy and Birch, {J. M.} and Draper, {G. J.} and Hungerford, {J. L.} and Kingston, {J. E.} and Kroll, {M. E.} and Z. Onadim and Stiller, {C. A.} and Vincent, {T. J.} and Murphy, {M. F G}",

note = "MacCarthy, A Birch, J M Draper, G J Hungerford, J L Kingston, J E Kroll, M E Onadim, Z Stiller, C A Vincent, T J Murphy, M F G Department of Health/United Kingdom Research Support, Non-U.S. Gov't England The British journal of ophthalmology Br J Ophthalmol. 2009 Jan;93(1):33-7. doi: 10.1136/bjo.2008.139618. Epub 2008 Oct 6.",

year = "2009",

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doi = "10.1136/bjo.2008.139618",

language = "English",

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journal = "British Journal Of Ophthalmology",

issn = "0007-1161",

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AU - MacCarthy, A.

AU - Birch, J. M.

AU - Draper, G. J.

AU - Hungerford, J. L.

AU - Kingston, J. E.

AU - Kroll, M. E.

AU - Onadim, Z.

AU - Stiller, C. A.

AU - Vincent, T. J.

AU - Murphy, M. F G

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PY - 2009/1

Y1 - 2009/1

N2 - Aim: This paper describes the epidemiology and family history status of 1601 children with retinoblastoma in Great Britain diagnosed 1963-2002 and summarises the practical consequences for diagnosis and counselling of developments in molecular genetics. Methods: Incidence rates were analysed according to year of diagnosis and tumour laterality. Cases were classified as heritable or non-heritable on the basis of laterality and family history of the disease. Results: There were 998 unilateral cases, 581 bilateral and 22 of unknown laterality. Bilateral cases tended to be diagnosed at a younger age than unilateral. All bilateral cases are regarded as heritable, and 35% had a family history of the disease. 7% of the unilateral cases had a family history and are therefore heritable. Thus, at least (41%) of our cases are heritable. This is an underestimate, since these data on family history are incomplete. For unilateral cases aged below 1 year, the reported incidence rate increased significantly (p

AB - Aim: This paper describes the epidemiology and family history status of 1601 children with retinoblastoma in Great Britain diagnosed 1963-2002 and summarises the practical consequences for diagnosis and counselling of developments in molecular genetics. Methods: Incidence rates were analysed according to year of diagnosis and tumour laterality. Cases were classified as heritable or non-heritable on the basis of laterality and family history of the disease. Results: There were 998 unilateral cases, 581 bilateral and 22 of unknown laterality. Bilateral cases tended to be diagnosed at a younger age than unilateral. All bilateral cases are regarded as heritable, and 35% had a family history of the disease. 7% of the unilateral cases had a family history and are therefore heritable. Thus, at least (41%) of our cases are heritable. This is an underestimate, since these data on family history are incomplete. For unilateral cases aged below 1 year, the reported incidence rate increased significantly (p

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KW - Age Distribution

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KW - Child, Preschool

KW - Female

KW - Genetic Counseling

KW - Great Britain/epidemiology

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Registries/statistics & numerical data

KW - Retinal Neoplasms/ epidemiology/pathology

KW - Retinoblastoma/ epidemiology/pathology

KW - Sex Distribution

KW - Time Factors

U2 - 10.1136/bjo.2008.139618

DO - 10.1136/bjo.2008.139618

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SP - 33

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JO - British Journal Of Ophthalmology

JF - British Journal Of Ophthalmology

IS - 1

ER -

Retinoblastoma in Great Britain 1963-2002

Abstract

Keywords

UN SDGs

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