Revascularisation strategies in patients with significant left main coronary disease during the COVID-19 pandemic

Mohamed O Mohames, Nick Curzen, Mark de Belder, Andrew T Goodwin, James C Spratt, Lognathen Balacumaraswami, John Deanfield, Glen Martin, Muhammad Rashid, Ahmad Shoaib, Chris P Gale, Tim Kinnaird, Mamas A Mamas

Research output: Contribution to journalArticlepeer-review


Background: There are limited data on the impact of the COVID-19 pandemic on left main (LM) coronary revascularisation activity, choice of revascularisation strategy and post-procedural outcomes.

Methods: All patients with LM disease (≥50% stenosis) undergoing coronary revascularisation in England between 01/01/2017 and 19/8/2020 were included (n=22,235), stratified by time-period (pre-COVID: 01/01/2017-29/2/2020; COVID: 1/3/2020-19/8/2020) and revascularisation strategy (percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG). Logistic regression models were performed to examine odds ratio (OR) of 1) receipt of CABG (vs. PCI) and 2) in-hospital and 30-day postprocedural mortality, in the COVID-19 period (vs. pre-COVID).

Results: There was a decline of 1,354 LM revascularisation procedures between 1st March and 31st July 2020 compared with previous years’ (2017-2019) averages (-48.8%). An increased utilisation of PCI over CABG was observed in the COVID period (receipt of CABG vs. PCI: OR 0.46 [0.39, 0.53] compared with 2017), consistent across all age groups. No difference in adjusted in-hospital or 30-day mortality was observed between pre-COVID and COVID periods for both PCI (odds ratio (OR): 0.72 [0.51. 1.02] and 0.83 [0.62, 1.11], respectively) and CABG (OR 0.98 [0.45, 2.14] and 1.51 [0.77, 2.98], respectively) groups.

Conclusion: LM revascularisation activity has significantly declined during the COVID period, with a shift towards PCI as the preferred strategy. Postprocedural mortality within each revascularisation group was similar in the pre-COVID and COVID periods, reflecting maintenance in quality of outcomes during the pandemic. Future measures are required to safely restore LM revascularisation activity to pre-COVID levels.
Original languageEnglish
JournalCatheterization and Cardiovascular Interventions
Publication statusAccepted/In press - 16 Mar 2021


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