Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

Adrian R Parry-Jones; Mario Di Napoli; Joshua N Goldstein; Floris H B M Schreuder; Sami Tetri; Turgut Tatlisumak; Bernard Yan; Koen M van Nieuwenhuizen; Nelly Dequatre-Ponchelle; Matthew Lee-Archer; Solveig Horstmann; Duncan Wilson; Fulvio Pomero; Luca Masotti; Christine Lerpiniere; Daniel Augustin Godoy; Abigail S Cohen; Rik Houben; Rustam Al-Shahi Salman; Paolo Pennati; Luigi Fenoglio; David Werring; Roland Veltkamp; Edith Wood; Helen M Dewey; Charlotte Cordonnier; Catharina J M Klijn; Fabrizio Meligeni; Stephen M Davis; Juha Huhtakangas; Julie Staals; Jonathan Rosand; Atte Meretoja

doi:10.1002/ana.24416

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

Adrian R Parry-Jones, Mario Di Napoli, Joshua N Goldstein, Floris H B M Schreuder, Sami Tetri, Turgut Tatlisumak, Bernard Yan, Koen M van Nieuwenhuizen, Nelly Dequatre-Ponchelle, Matthew Lee-Archer, Solveig Horstmann, Duncan Wilson, Fulvio Pomero, Luca Masotti, Christine Lerpiniere, Daniel Augustin Godoy, Abigail S Cohen, Rik Houben, Rustam Al-Shahi Salman, Paolo PennatiLuigi Fenoglio, David Werring, Roland Veltkamp, Edith Wood, Helen M Dewey, Charlotte Cordonnier, Catharina J M Klijn, Fabrizio Meligeni, Stephen M Davis, Juha Huhtakangas, Julie Staals, Jonathan Rosand, Atte Meretoja

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR

Original language	English
Journal	Annals of Neurology
DOIs	https://doi.org/10.1002/ana.24416
Publication status	Published - 8 Apr 2015

Keywords

Anticoagulation
Intracerebral hemorrhage
Reversal

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10.1002/ana.24416

Reducing mortality via the ‘ABC’ care bundle for intracerebral haemorrhage (ICH)
Adrian Parry-Jones (Participant), Hiren Patel (Participant), Matthew Sutton (Participant), Paul Wilson (Participant) & Lisa Brunton (Participant)
Impact: Health and wellbeing

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Parry-Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre-Ponchelle, N., Lee-Archer, M., Horstmann, S., Wilson, D., Pomero, F., Masotti, L., Lerpiniere, C., Godoy, D. A., Cohen, A. S., Houben, R., Al-Shahi Salman, R., ... Meretoja, A. (2015). Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology. https://doi.org/10.1002/ana.24416

@article{ae443fdd1380491f93a54ade93081d58,

title = "Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.",

abstract = "OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR",

keywords = "Anticoagulation, Intracerebral hemorrhage, Reversal",

author = "Parry-Jones, {Adrian R} and {Di Napoli}, Mario and Goldstein, {Joshua N} and Schreuder, {Floris H B M} and Sami Tetri and Turgut Tatlisumak and Bernard Yan and {van Nieuwenhuizen}, {Koen M} and Nelly Dequatre-Ponchelle and Matthew Lee-Archer and Solveig Horstmann and Duncan Wilson and Fulvio Pomero and Luca Masotti and Christine Lerpiniere and Godoy, {Daniel Augustin} and Cohen, {Abigail S} and Rik Houben and {Al-Shahi Salman}, Rustam and Paolo Pennati and Luigi Fenoglio and David Werring and Roland Veltkamp and Edith Wood and Dewey, {Helen M} and Charlotte Cordonnier and Klijn, {Catharina J M} and Fabrizio Meligeni and Davis, {Stephen M} and Juha Huhtakangas and Julie Staals and Jonathan Rosand and Atte Meretoja",

year = "2015",

month = apr,

day = "8",

doi = "10.1002/ana.24416",

language = "English",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley & Sons Ltd",

}

Parry-Jones, AR, Di Napoli, M, Goldstein, JN, Schreuder, FHBM, Tetri, S, Tatlisumak, T, Yan, B, van Nieuwenhuizen, KM, Dequatre-Ponchelle, N, Lee-Archer, M, Horstmann, S, Wilson, D, Pomero, F, Masotti, L, Lerpiniere, C, Godoy, DA, Cohen, AS, Houben, R, Al-Shahi Salman, R, Pennati, P, Fenoglio, L, Werring, D, Veltkamp, R, Wood, E, Dewey, HM, Cordonnier, C, Klijn, CJM, Meligeni, F, Davis, SM, Huhtakangas, J, Staals, J, Rosand, J & Meretoja, A 2015, 'Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.', Annals of Neurology. https://doi.org/10.1002/ana.24416

TY - JOUR

T1 - Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

AU - Parry-Jones, Adrian R

AU - Di Napoli, Mario

AU - Goldstein, Joshua N

AU - Schreuder, Floris H B M

AU - Tetri, Sami

AU - Tatlisumak, Turgut

AU - Yan, Bernard

AU - van Nieuwenhuizen, Koen M

AU - Dequatre-Ponchelle, Nelly

AU - Lee-Archer, Matthew

AU - Horstmann, Solveig

AU - Wilson, Duncan

AU - Pomero, Fulvio

AU - Masotti, Luca

AU - Lerpiniere, Christine

AU - Godoy, Daniel Augustin

AU - Cohen, Abigail S

AU - Houben, Rik

AU - Al-Shahi Salman, Rustam

AU - Pennati, Paolo

AU - Fenoglio, Luigi

AU - Werring, David

AU - Veltkamp, Roland

AU - Wood, Edith

AU - Dewey, Helen M

AU - Cordonnier, Charlotte

AU - Klijn, Catharina J M

AU - Meligeni, Fabrizio

AU - Davis, Stephen M

AU - Huhtakangas, Juha

AU - Staals, Julie

AU - Rosand, Jonathan

AU - Meretoja, Atte

PY - 2015/4/8

Y1 - 2015/4/8

N2 - OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR

AB - OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR

KW - Anticoagulation

KW - Intracerebral hemorrhage

KW - Reversal

U2 - 10.1002/ana.24416

DO - 10.1002/ana.24416

M3 - Article

C2 - 25857223

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

ER -

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

Abstract

Keywords

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Impacts

Reducing mortality via the ‘ABC’ care bundle for intracerebral haemorrhage (ICH)

Cite this