Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

Adrian R Parry-Jones, Mario Di Napoli, Joshua N Goldstein, Floris H B M Schreuder, Sami Tetri, Turgut Tatlisumak, Bernard Yan, Koen M van Nieuwenhuizen, Nelly Dequatre-Ponchelle, Matthew Lee-Archer, Solveig Horstmann, Duncan Wilson, Fulvio Pomero, Luca Masotti, Christine Lerpiniere, Daniel Augustin Godoy, Abigail S Cohen, Rik Houben, Rustam Al-Shahi Salman, Paolo PennatiLuigi Fenoglio, David Werring, Roland Veltkamp, Edith Wood, Helen M Dewey, Charlotte Cordonnier, Catharina J M Klijn, Fabrizio Meligeni, Stephen M Davis, Juha Huhtakangas, Julie Staals, Jonathan Rosand, Atte Meretoja

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR
    Original languageEnglish
    JournalAnnals of Neurology
    DOIs
    Publication statusPublished - 8 Apr 2015

    Keywords

    • Anticoagulation
    • Intracerebral hemorrhage
    • Reversal

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