Abstract
Over the past decade many well-tried chemotherapeutic agents have lost their effectiveness. This is due to a phenomenon referred to as multi-drug resistance. The most likely cause of multi-drug resistance is an increase in the activity of an efflux pump mediated through the actions of a P-glycoprotein. There is a continuing search, not only for new chemotherapeutic agents, but also for agents that can reverse the acquired resistance to existing agents.
| Original language | English |
|---|---|
| Pages (from-to) | 1023-1032 |
| Number of pages | 9 |
| Journal | Expert Opinion on Investigational Drugs |
| Volume | 11 |
| Issue number | 8 |
| Publication status | Published - 2002 |
Keywords
- Multi-drug resistance
- Multidrug resistance reversal agents
- Multiple resistance protein
- P-glycoprotein
- P-glycoprotein inhibitors
