Review: Recent progress in frontotemporal lobar degeneration

S. M. Pickering-Brown

    Research output: Contribution to journalArticlepeer-review


    Frontotemporal lobar degeneration (FTLD) is a highly familial condition and is increasingly being recognized as an important form of dementia. The literature published on this disease is often difficult to collate due to the wide range in nomenclature used. Thankfully, consensus recommendations have now been published to address this issue and hopefully the community will adopt these as intended. Much progress has been made in our understanding of the clinical, pathological and genetic understanding of FTLD in recent years. Progranulin and TDP-43 have recently been identified as new important proteins involved in the pathophysiology of FTLD and this latter protein may have potential as a biomarker of this disease. However, much remains before we have a full picture of the genes that cause FTLD and the biological pathways in which they function. The purpose of this review is to summarize the current concepts and recent advances in our knowledge of this disease. © 2010 Blackwell Publishing Ltd.
    Original languageEnglish
    Pages (from-to)4-16
    Number of pages12
    JournalNeuropathology and Applied Neurobiology
    Issue number1
    Publication statusPublished - 2010


    • Frontotemporal lobar degeneration
    • Progranulin
    • Tau
    • TDP-43
    • UBAP1

    Research Beacons, Institutes and Platforms

    • Dementia@Manchester


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