Rfam: Annotating non-coding RNAs in complete genomes

Sam Griffiths-Jones; Simon Moxon; Mhairi Marshall; Ajay Khanna; Sean R. Eddy; Alex Bateman

doi:10.1093/nar/gki081

Rfam: Annotating non-coding RNAs in complete genomes

Sam Griffiths-Jones, Simon Moxon, Mhairi Marshall, Ajay Khanna, Sean R. Eddy, Alex Bateman

Research output: Contribution to journal › Article › peer-review

Abstract

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. © Oxford University Press 2005; all rights reserved.

Original language	English
Pages (from-to)	D121-D124
Journal	Nucleic acids research.
Volume	33
DOIs	https://doi.org/10.1093/nar/gki081
Publication status	Published - 1 Jan 2005

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abstract = "Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. {\textcopyright} Oxford University Press 2005; all rights reserved.",

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doi = "10.1093/nar/gki081",

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AU - Griffiths-Jones, Sam

AU - Moxon, Simon

AU - Marshall, Mhairi

AU - Khanna, Ajay

AU - Eddy, Sean R.

AU - Bateman, Alex

PY - 2005/1/1

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N2 - Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. © Oxford University Press 2005; all rights reserved.

AB - Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. © Oxford University Press 2005; all rights reserved.

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DO - 10.1093/nar/gki081

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SP - D121-D124

JO - Nucleic acids research.

JF - Nucleic acids research.

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Rfam: Annotating non-coding RNAs in complete genomes

Abstract

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