Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton; Wendy Thomson; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Darren Plant; Laura J. Gibbons; Anthony G. Wilson; Deborah E. Bax; Ann W. Morgan; Paul Emery; Sophia Steer; Lynne Hocking; David M. Reid; Paul Wordsworth; Pille Harrison; Jane Worthington

doi:10.1038/ng.218

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J. Gibbons, Anthony G. Wilson, Deborah E. Bax, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M. Reid, Paul Wordsworth, Pille Harrison, Jane Worthington

Research output: Contribution to journal › Article › peer-review

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10-4 - 1 × 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10-5, P = 4 × 10-4 and P = 4 × 10 -4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Original language	English
Pages (from-to)	1156-1159
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	10
DOIs	https://doi.org/10.1038/ng.218
Publication status	Published - Oct 2008

Keywords

genetics: Arthritis, Rheumatoid
Case-Control Studies
Chromosome Mapping
genetics: Chromosomes, Human, Pair 10
genetics: Chromosomes, Human, Pair 12
genetics: Chromosomes, Human, Pair 22
genetics: Genetic Predisposition to Disease
Humans
Linkage (Genetics)
genetics: Polymorphism, Single Nucleotide

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Barton, A., Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., Plant, D., Gibbons, L. J., Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., Harrison, P., & Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40(10), 1156-1159. https://doi.org/10.1038/ng.218

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title = "Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13",

abstract = "The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10-4 - 1 × 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10-5, P = 4 × 10-4 and P = 4 × 10 -4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.",

keywords = "genetics: Arthritis, Rheumatoid, Case-Control Studies, Chromosome Mapping, genetics: Chromosomes, Human, Pair 10, genetics: Chromosomes, Human, Pair 12, genetics: Chromosomes, Human, Pair 22, genetics: Genetic Predisposition to Disease, Humans, Linkage (Genetics), genetics: Polymorphism, Single Nucleotide",

author = "Anne Barton and Wendy Thomson and Xiayi Ke and Steve Eyre and Anne Hinks and John Bowes and Darren Plant and Gibbons, {Laura J.} and Wilson, {Anthony G.} and Bax, {Deborah E.} and Morgan, {Ann W.} and Paul Emery and Sophia Steer and Lynne Hocking and Reid, {David M.} and Paul Wordsworth and Pille Harrison and Jane Worthington",

year = "2008",

month = oct,

doi = "10.1038/ng.218",

language = "English",

volume = "40",

pages = "1156--1159",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Springer Nature",

number = "10",

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TY - JOUR

T1 - Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

AU - Barton, Anne

AU - Thomson, Wendy

AU - Ke, Xiayi

AU - Eyre, Steve

AU - Hinks, Anne

AU - Bowes, John

AU - Plant, Darren

AU - Gibbons, Laura J.

AU - Wilson, Anthony G.

AU - Bax, Deborah E.

AU - Morgan, Ann W.

AU - Emery, Paul

AU - Steer, Sophia

AU - Hocking, Lynne

AU - Reid, David M.

AU - Wordsworth, Paul

AU - Harrison, Pille

AU - Worthington, Jane

PY - 2008/10

Y1 - 2008/10

N2 - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10-4 - 1 × 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10-5, P = 4 × 10-4 and P = 4 × 10 -4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

AB - The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10-4 - 1 × 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10-5, P = 4 × 10-4 and P = 4 × 10 -4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

KW - genetics: Arthritis, Rheumatoid

KW - Case-Control Studies

KW - Chromosome Mapping

KW - genetics: Chromosomes, Human, Pair 10

KW - genetics: Chromosomes, Human, Pair 12

KW - genetics: Chromosomes, Human, Pair 22

KW - genetics: Genetic Predisposition to Disease

KW - Humans

KW - Linkage (Genetics)

KW - genetics: Polymorphism, Single Nucleotide

U2 - 10.1038/ng.218

DO - 10.1038/ng.218

M3 - Article

SN - 1061-4036

VL - 40

SP - 1156

EP - 1159

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

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Keywords

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