Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Anne Barton, Wendy Thomson, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Darren Plant, Laura J. Gibbons, Anthony G. Wilson, Deborah E. Bax, Ann W. Morgan, Paul Emery, Sophia Steer, Lynne Hocking, David M. Reid, Paul Wordsworth, Pille Harrison, Jane Worthington

    Research output: Contribution to journalArticlepeer-review


    The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10-4 - 1 × 10-5 (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10-5, P = 4 × 10-4 and P = 4 × 10 -4, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
    Original languageEnglish
    Pages (from-to)1156-1159
    Number of pages3
    JournalNature Genetics
    Issue number10
    Publication statusPublished - Oct 2008


    • genetics: Arthritis, Rheumatoid
    • Case-Control Studies
    • Chromosome Mapping
    • genetics: Chromosomes, Human, Pair 10
    • genetics: Chromosomes, Human, Pair 12
    • genetics: Chromosomes, Human, Pair 22
    • genetics: Genetic Predisposition to Disease
    • Humans
    • Linkage (Genetics)
    • genetics: Polymorphism, Single Nucleotide


    Dive into the research topics of 'Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13'. Together they form a unique fingerprint.

    Cite this