TY - JOUR
T1 - Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma
AU - Megremis, Spyridon
AU - Niespodziana, Katarzyna
AU - Cabauatan, Clarissa
AU - Xepapadaki, Paraskevi
AU - Kowalski, Marek L
AU - Jartti, Tuomas
AU - Bachert, Claus
AU - Finotto, Susetta
AU - West, Peter
AU - Stamataki, Sofia
AU - Lewandowska-Polak, Anna
AU - Lukkarinen, Heikki
AU - Zhang, Nan
AU - Zimmermann, Theodor
AU - Stolz, Frank
AU - Neubauer, Angela
AU - Akdis, Mübeccel
AU - Andreakos, Evangelos
AU - Valenta, Rudolf
AU - Papadopoulos, Nikolaos G
N1 - Funding Information:
Supported by the European Commission’s Seventh Framework program (260895 [PREDICTA]), by the Austrian Science Fund (project P29398-B30), and by research grants from Biomay AG and Viravaxx AG, Vienna, Austria.
Publisher Copyright:
Copyright © 2018 by the American Thoracic Society.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/12/15
Y1 - 2018/12/15
N2 - RATIONALE: Rhinoviruses are major triggers of common cold and acute asthma exacerbations; Rhinovirus species A, B and C may have distinct clinical impact; however, little is known regarding RV species-specific antibody responses in health and asthma.OBJECTIVES: To describe and compare total and rhinovirus species-specific antibody levels in healthy and asthmatic children, away from an acute event.METHODS: Serum samples from 163 preschool children with mild to moderate asthma and 72 healthy controls from the multinational Predicta cohort were analysed using the recently developed PreDicta rhinovirus antibody chip.MAIN RESULTS: Rhinovirus antibody levels varied, with rhinovirus C and rhinovirus A being higher than rhinovirus B in both groups. Compared to controls, asthma was characterised by significantly higher levels of antibodies to rhinovirus A and rhinovirus C, but not rhinovirus B. Rhinovirus antibody levels positively correlated with the number of common colds over the previous year in healthy children, and wheeze episodes in asthmatics. Antibody levels also positively correlated with asthma severity but not with current asthma control.CONCLUSIONS: The variable humoral response to rhinovirus species in both groups, suggests a differential infectivity pattern between rhinovirus species. In healthy pre-schoolers, rhinovirus antibodies accumulate with colds. In asthma, rhinovirus A and rhinovirus C antibodies are much higher and further increase with disease severity and wheeze episodes. Higher antibody levels in asthma may be due to a compromised innate immune response, leading to increased exposure of the adaptive immunity to the virus. Importantly, there is no apparent protection with increasing levels of antibodies.
AB - RATIONALE: Rhinoviruses are major triggers of common cold and acute asthma exacerbations; Rhinovirus species A, B and C may have distinct clinical impact; however, little is known regarding RV species-specific antibody responses in health and asthma.OBJECTIVES: To describe and compare total and rhinovirus species-specific antibody levels in healthy and asthmatic children, away from an acute event.METHODS: Serum samples from 163 preschool children with mild to moderate asthma and 72 healthy controls from the multinational Predicta cohort were analysed using the recently developed PreDicta rhinovirus antibody chip.MAIN RESULTS: Rhinovirus antibody levels varied, with rhinovirus C and rhinovirus A being higher than rhinovirus B in both groups. Compared to controls, asthma was characterised by significantly higher levels of antibodies to rhinovirus A and rhinovirus C, but not rhinovirus B. Rhinovirus antibody levels positively correlated with the number of common colds over the previous year in healthy children, and wheeze episodes in asthmatics. Antibody levels also positively correlated with asthma severity but not with current asthma control.CONCLUSIONS: The variable humoral response to rhinovirus species in both groups, suggests a differential infectivity pattern between rhinovirus species. In healthy pre-schoolers, rhinovirus antibodies accumulate with colds. In asthma, rhinovirus A and rhinovirus C antibodies are much higher and further increase with disease severity and wheeze episodes. Higher antibody levels in asthma may be due to a compromised innate immune response, leading to increased exposure of the adaptive immunity to the virus. Importantly, there is no apparent protection with increasing levels of antibodies.
KW - Antibody
KW - Asthma
KW - PreDicta chip
KW - Rhinovirus
UR - http://www.scopus.com/inward/record.url?scp=85058784732&partnerID=8YFLogxK
U2 - 10.1164/rccm.201803-0575OC
DO - 10.1164/rccm.201803-0575OC
M3 - Article
C2 - 30134114
SN - 1073-449X
VL - 198
SP - 1490
EP - 1499
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 12
ER -