Ribosomal acrobatics in post-transcriptional control

John Mccarthy, R. J C Gilbert, Ian Brierley, J. E G McCarthy

    Research output: Contribution to journalArticlepeer-review


    High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding of the higher dynamics of the ribosome accompanying active recruitment of mRNA to the small subunit and translocation of tRNAs. Recent data show that careful use of a variety of different techniques is necessary for a proper understanding of the basis of function in systems such as the ribosome. © The Authors Journal compilation © 2008 Biochemical Society.
    Original languageEnglish
    Pages (from-to)677-683
    Number of pages6
    JournalBiochemical Society Transactions
    Issue number4
    Publication statusPublished - Aug 2008


    • Cryo-electron microscopy
    • Crystal structure
    • Initiation factor 1 (IF1)
    • Ligand bending
    • Ribosome
    • Translation


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