Ribosomal acrobatics in post-transcriptional control

John Mccarthy; R. J C Gilbert; Ian Brierley; J. E G McCarthy

doi:10.1042/BST0360677

Ribosomal acrobatics in post-transcriptional control

John Mccarthy, R. J C Gilbert, Ian Brierley, J. E G McCarthy

Research output: Contribution to journal › Article › peer-review

Abstract

High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding of the higher dynamics of the ribosome accompanying active recruitment of mRNA to the small subunit and translocation of tRNAs. Recent data show that careful use of a variety of different techniques is necessary for a proper understanding of the basis of function in systems such as the ribosome. © The Authors Journal compilation © 2008 Biochemical Society.

Original language	English
Pages (from-to)	677-683
Number of pages	6
Journal	Biochemical Society Transactions
Volume	36
Issue number	4
DOIs	https://doi.org/10.1042/BST0360677
Publication status	Published - Aug 2008

Keywords

Cryo-electron microscopy
Crystal structure
Initiation factor 1 (IF1)
Ligand bending
Ribosome
Translation

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10.1042/BST0360677

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title = "Ribosomal acrobatics in post-transcriptional control",

abstract = "High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding of the higher dynamics of the ribosome accompanying active recruitment of mRNA to the small subunit and translocation of tRNAs. Recent data show that careful use of a variety of different techniques is necessary for a proper understanding of the basis of function in systems such as the ribosome. {\textcopyright} The Authors Journal compilation {\textcopyright} 2008 Biochemical Society.",

keywords = "Cryo-electron microscopy, Crystal structure, Initiation factor 1 (IF1), Ligand bending, Ribosome, Translation",

author = "John Mccarthy and Gilbert, {R. J C} and Ian Brierley and McCarthy, {J. E G}",

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AU - Brierley, Ian

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AB - High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding of the higher dynamics of the ribosome accompanying active recruitment of mRNA to the small subunit and translocation of tRNAs. Recent data show that careful use of a variety of different techniques is necessary for a proper understanding of the basis of function in systems such as the ribosome. © The Authors Journal compilation © 2008 Biochemical Society.

KW - Cryo-electron microscopy

KW - Crystal structure

KW - Initiation factor 1 (IF1)

KW - Ligand bending

KW - Ribosome

KW - Translation

U2 - 10.1042/BST0360677

DO - 10.1042/BST0360677

M3 - Article

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SP - 677

EP - 683

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Ribosomal acrobatics in post-transcriptional control

Abstract

Keywords

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