Ribosomes and Stress - Linked from Birth to Death

J. R.P. Knight, T. Sbarrato, M. Stoneley, A. E. Willis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Ribosomes are molecular machines that translate the genome into protein. They consume a large amount of energy, linking ribosomes to cellular energy management. This is one facet of ribosome stress, which we describe as a two-way process. Ribosomes are regulated by stress signaling, such as energy status, but also sense stress and enact appropriate responses. Stress sensing starts at ribosomes synthesis, which is linked to cell fate by ribosome components and biogenesis factors. Importantly, the working ribosome also senses stress-inducing aberrations, and has mechanisms to reduce their likelihood. Finally, even ribosome degradation is a regulated part of the stress response.

Original languageEnglish
Title of host publicationFunctional Cell Biology
PublisherElsevier BV
Number of pages11
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
Publication statusPublished - 2016


  • Nucleolar stress
  • P53
  • Quality control
  • Ribosome function
  • Stress response
  • Translation

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre


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