Role of adhesion receptor trafficking in 3D cell migration

Guillaume Jacquemet, Martin J Humphries, Patrick Caswell

Research output: Contribution to journalArticlepeer-review


This review discusses recent advances in our understanding of adhesion receptor trafficking in vitro, and extrapolates them as far as what is currently possible towards an understanding of migration in three dimensions in vivo. Our specific focus is the mechanisms for endocytosis and recycling of the two major classes of cell-matrix adhesion receptors, integrins and syndecans. We review the signalling networks that are employed to regulate trafficking and conversely the effects of trafficking on signalling itself. We then define the contribution that this element of the migration process makes to processes such as wound healing and tumour invasion. © 2013 The Authors.
Original languageEnglish
Pages (from-to)627-632
Number of pages5
JournalCurrent opinion in cell biology
Issue number5
Early online date21 Jun 2013
Publication statusPublished - Oct 2013


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