Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study

T. V. Macfarlane; G. J. Macfarlane; N. S. Thakker; S. Benhamou; C. Bouchardy; W. Ahrens; H. Pohlabeln; P. Lagiou; A. Lagiou; X. Castellsague; A. Agudo; A. Slamova; J. Plzak; F. Merletti; L. Richiardi; R. Talamini; L. Barzan; K. Kjaerheim; C. Canova; L. Simonato; D. I. Conway; P. A. Mckinney; P. Thomson; P. Sloan; A. Znaor; C. M. Healy; B. E. McCartan; M. Marron; P. Brennan

doi:10.1093/annonc/mdr335

Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study

T. V. Macfarlane, G. J. Macfarlane, N. S. Thakker, S. Benhamou, C. Bouchardy, W. Ahrens, H. Pohlabeln, P. Lagiou, A. Lagiou, X. Castellsague, A. Agudo, A. Slamova, J. Plzak, F. Merletti, L. Richiardi, R. Talamini, L. Barzan, K. Kjaerheim, C. Canova, L. SimonatoD. I. Conway, P. A. Mckinney, P. Thomson, P. Sloan, A. Znaor, C. M. Healy, B. E. McCartan, M. Marron, P. Brennan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

Original language	English
Pages (from-to)	1053-1060
Number of pages	7
Journal	Annals of Oncology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1093/annonc/mdr335
Publication status	Published - Apr 2012

Keywords

Aspirin use
Epidemiology
Gastroesophageal reflux
Medical history
Medication use
Upper aerodigestive tract cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Macfarlane, T. V., Macfarlane, G. J., Thakker, N. S., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A., Castellsague, X., Agudo, A., Slamova, A., Plzak, J., Merletti, F., Richiardi, L., Talamini, R., Barzan, L., Kjaerheim, K., Canova, C., ... Brennan, P. (2012). Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study. Annals of Oncology, 23(4), 1053-1060. https://doi.org/10.1093/annonc/mdr335

@article{918fc06d2c414d8bb04a01fdf57eebc2,

title = "Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study",

abstract = "Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. {\textcopyright} The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.",

keywords = "Aspirin use, Epidemiology, Gastroesophageal reflux, Medical history, Medication use, Upper aerodigestive tract cancer",

author = "Macfarlane, {T. V.} and Macfarlane, {G. J.} and Thakker, {N. S.} and S. Benhamou and C. Bouchardy and W. Ahrens and H. Pohlabeln and P. Lagiou and A. Lagiou and X. Castellsague and A. Agudo and A. Slamova and J. Plzak and F. Merletti and L. Richiardi and R. Talamini and L. Barzan and K. Kjaerheim and C. Canova and L. Simonato and Conway, {D. I.} and Mckinney, {P. A.} and P. Thomson and P. Sloan and A. Znaor and Healy, {C. M.} and McCartan, {B. E.} and M. Marron and P. Brennan",

year = "2012",

month = apr,

doi = "10.1093/annonc/mdr335",

language = "English",

volume = "23",

pages = "1053--1060",

journal = "Annals of Oncology",

issn = "1569-8041",

publisher = "Oxford University Press",

number = "4",

}

Macfarlane, TV, Macfarlane, GJ, Thakker, NS, Benhamou, S, Bouchardy, C, Ahrens, W, Pohlabeln, H, Lagiou, P, Lagiou, A, Castellsague, X, Agudo, A, Slamova, A, Plzak, J, Merletti, F, Richiardi, L, Talamini, R, Barzan, L, Kjaerheim, K, Canova, C, Simonato, L, Conway, DI, Mckinney, PA, Thomson, P, Sloan, P, Znaor, A, Healy, CM, McCartan, BE, Marron, M & Brennan, P 2012, 'Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study', Annals of Oncology, vol. 23, no. 4, pp. 1053-1060. https://doi.org/10.1093/annonc/mdr335

TY - JOUR

T1 - Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study

AU - Macfarlane, T. V.

AU - Macfarlane, G. J.

AU - Thakker, N. S.

AU - Benhamou, S.

AU - Bouchardy, C.

AU - Ahrens, W.

AU - Pohlabeln, H.

AU - Lagiou, P.

AU - Lagiou, A.

AU - Castellsague, X.

AU - Agudo, A.

AU - Slamova, A.

AU - Plzak, J.

AU - Merletti, F.

AU - Richiardi, L.

AU - Talamini, R.

AU - Barzan, L.

AU - Kjaerheim, K.

AU - Canova, C.

AU - Simonato, L.

AU - Conway, D. I.

AU - Mckinney, P. A.

AU - Thomson, P.

AU - Sloan, P.

AU - Znaor, A.

AU - Healy, C. M.

AU - McCartan, B. E.

AU - Marron, M.

AU - Brennan, P.

PY - 2012/4

Y1 - 2012/4

N2 - Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

AB - Background: The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn; for regurgitation; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer.Methods: A multicentre (10 European countries) case-control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. Results: There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68-0.94 and OR 0.73, 95% CI 0.60-0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98-2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28-0.96), hypopharynx (OR 0.53, 95% CI 0.28-1.02) and larynx (OR 0.74, 95% CI 0.54-1.01). Conclusions: A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

KW - Aspirin use

KW - Epidemiology

KW - Gastroesophageal reflux

KW - Medical history

KW - Medication use

KW - Upper aerodigestive tract cancer

U2 - 10.1093/annonc/mdr335

DO - 10.1093/annonc/mdr335

M3 - Article

C2 - 21828376

SN - 1569-8041

VL - 23

SP - 1053

EP - 1060

JO - Annals of Oncology

JF - Annals of Oncology

IS - 4

ER -

Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: The ARCAGE study

Abstract

Keywords

UN SDGs

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