Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy

Azadeh Abravan, Gareth Price, Kathryn Banfill, Tom Merchant, Matthew Craddock, Joe Wood, Marianne Camille Aznar, Alan Mcwilliam, Marcel Van Herk, Corinne Faivre-Finn

Research output: Contribution to journalArticlepeer-review

Abstract

Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints.
Original languageEnglish
JournalFrontiers in Oncology
Publication statusAccepted/In press - 13 Jun 2022

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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