Role of Serological Tests in the Diagnosis of Mould Infections

Malcolm Richardson; Iain Page

doi:10.1007/s12281-018-0321-1

Role of Serological Tests in the Diagnosis of Mould Infections

Malcolm Richardson, Iain Page

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose of review: to understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (moulds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated.

Recent findings: this article reviews the current antibody detection systems (serological tests) for the diagnosis of mould infections associated with pulmonary disease, and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation and ELISA

Summary: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous Basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing.

Original language	English
Pages (from-to)	127-136
Number of pages	10
Journal	Current Fungal Infection Reports
Volume	123
Early online date	5 Sept 2018
DOIs	https://doi.org/10.1007/s12281-018-0321-1
Publication status	Published - Sept 2018

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title = "Role of Serological Tests in the Diagnosis of Mould Infections",

abstract = "Purpose of review: to understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (moulds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. Recent findings: this article reviews the current antibody detection systems (serological tests) for the diagnosis of mould infections associated with pulmonary disease, and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation and ELISA Summary: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous Basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing.",

author = "Malcolm Richardson and Iain Page",

year = "2018",

month = sep,

doi = "10.1007/s12281-018-0321-1",

language = "English",

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AU - Page, Iain

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AB - Purpose of review: to understand the role of antibody detection in the diagnosis of infections caused by filamentous fungi (moulds). Rapid and accurate profiling of infection-causing fungal pathogens remains a significant challenge in modern health care. Classical fungal culture and serology continue to be relevant even though over the past few decades antigen (biomarker) assays such as ELISA and lateral flow devices have been developed and validated. Recent findings: this article reviews the current antibody detection systems (serological tests) for the diagnosis of mould infections associated with pulmonary disease, and introduces new developments. Classic and more recently developed serological techniques and their performance characteristics, including immunodiffusion, complement fixation and ELISA Summary: The diseases covered are allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, invasive aspergillosis, mucormycosis, diseases caused by filamentous Basidiomycetes, infection caused by Talaromyces marneffei and pythiosis. Serology remains a cornerstone for fungal diagnostic testing.

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JO - Current Fungal Infection Reports

JF - Current Fungal Infection Reports

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Role of Serological Tests in the Diagnosis of Mould Infections

Abstract

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