Role of the JAK-STAT pathway in myocardial injury

Seán P. Barry; Paul A. Townsend; David S. Latchman; Anastasis Stephanou

doi:10.1016/j.molmed.2006.12.002

Role of the JAK-STAT pathway in myocardial injury

Seán P. Barry, Paul A. Townsend, David S. Latchman, Anastasis Stephanou

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	82-89
Number of pages	7
Journal	Trends in molecular medicine
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/j.molmed.2006.12.002
Publication status	Published - Feb 2007

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10.1016/j.molmed.2006.12.002

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title = "Role of the JAK-STAT pathway in myocardial injury",

abstract = "Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

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AU - Barry, Seán P.

AU - Townsend, Paul A.

AU - Latchman, David S.

AU - Stephanou, Anastasis

PY - 2007/2

Y1 - 2007/2

N2 - Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy. © 2006 Elsevier Ltd. All rights reserved.

AB - Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy. © 2006 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.molmed.2006.12.002

M3 - Article

SN - 1471-4914

VL - 13

SP - 82

EP - 89

JO - Trends in molecular medicine

JF - Trends in molecular medicine

IS - 2

ER -

Role of the JAK-STAT pathway in myocardial injury

Abstract

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