Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics

Kwan Ting Kan, Joel Wilcock , Hui Lu

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein
and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in
the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging
from substrate degradation to the regulation of protein functions involved in mitochondrial
protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis
and signalling. In this mini review, we focus on discussing the current understanding of
the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and
signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial
dynamics.
Original languageEnglish
JournalBiochem Soc Trans
Publication statusPublished - 30 May 2024

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