RUNX transcription factors: orchestrators of development 1

Renaud Mevel; Julia Draper; Michael Lie-A-Ling; Valerie Kouskoff; Georges Lacaud

doi:10.1242/dev.148296

RUNX transcription factors: orchestrators of development 1

Renaud Mevel, Julia Draper, Michael Lie-A-Ling, Valerie Kouskoff, Georges Lacaud

Research output: Contribution to journal › Article › peer-review

Abstract

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes: RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their critical roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

Original language	English
Journal	Development
Volume	146
Issue number	17
DOIs	https://doi.org/10.1242/dev.148296
Publication status	Published - 5 Sept 2019

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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10.1242/dev.148296Licence: CC BY

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abstract = "RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes: RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their critical roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis. ",

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AU - Lacaud, Georges

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RUNX transcription factors: orchestrators of development 1

Abstract

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