Runx1 Structure and Function in Blood Cell Development

Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.

Original languageEnglish
Title of host publication Advances in Experimental Medicine and Biology
Number of pages17
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer Nature
ISSN (Print)0065-2598


  • Animals
  • Blood Cells/metabolism
  • Cell Differentiation/physiology
  • Chromatin/metabolism
  • Core Binding Factor Alpha 2 Subunit/metabolism
  • Hematologic Neoplasms/metabolism
  • Humans
  • Transcription Factors/metabolism
  • Transcription, Genetic/genetics


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