S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate

Vaibhav P. Mehta, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol. © 2013 American Chemical Society.
    Original languageEnglish
    Pages (from-to)5036-5039
    Number of pages3
    JournalOrganic Letters
    Issue number19
    Publication statusPublished - 4 Oct 2013


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