Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Bengt Fadeel; Cyrill Bussy; Sonia Merino; Ester Vázquez; Emmanuel Flahaut; Florence Mouchet; Lauris Evariste; Laury Gauthier; Antti J Koivisto; Ulla Vogel; Cristina Martin; Lucia G Delogu; Tina Bürki-Thurnherr; Peter Wick; Didier Beloin-Saint-Pierre; Roland Hischier; Marco Pelin; Fabio Candotto Carniel; Mauro Tretiach; Fabrizia Cesca; Fabio Benfenati; Denis Scaini; Laura Ballerini; Kostas Kostarelos; Maurizio Prato; Alberto Bianco

doi:10.1021/acsnano.8b04758

Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Bengt Fadeel, Cyrill Bussy, Sonia Merino, Ester Vázquez, Emmanuel Flahaut, Florence Mouchet, Lauris Evariste, Laury Gauthier, Antti J Koivisto, Ulla Vogel, Cristina Martin, Lucia G Delogu, Tina Bürki-Thurnherr, Peter Wick, Didier Beloin-Saint-Pierre, Roland Hischier, Marco Pelin, Fabio Candotto Carniel, Mauro Tretiach, Fabrizia CescaFabio Benfenati, Denis Scaini, Laura Ballerini, Kostas Kostarelos, Maurizio Prato, Alberto Bianco

Pharmacy

Research output: Contribution to journal › Article › peer-review

308 Downloads (Pure)

Abstract

Graphene and its derivatives are heralded as 'miracle' materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

Original language	English
Journal	ACS Nano
Early online date	2 Nov 2018
DOIs	https://doi.org/10.1021/acsnano.8b04758
Publication status	Published - 2018

Keywords

Graphene
Safety assessment
Health
Environment effects
2D materials
Characterisation
Life cycle assessment (LCA)
Exposure assessment
Hazard and risk assessment
Nanomaterials
Nanotoxicology

Research Beacons, Institutes and Platforms

Advanced materials
Advanced Materials in Medicine
Lydia Becker Institute
National Graphene Institute
Manchester Environmental Research Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acsnano.8b04758Licence: Other

FADEEL ET AL_SAFETY ASSESSMENT_GRAPHENE_ACS-NANO_ACCEPTED_2018-1-pages-deletedAccepted author manuscript, 2.2 MB

https://pubs.acs.org/doi/pdf/10.1021/acsnano.8b04758Licence: Other

2 Finished

Graphene Flagship Core 2 (Division of Pharmacy and Optometry allocation).
Kostarelos, K. (PI) & Bussy, C. (CoI)
1/04/18 → 31/03/20
Project: Research
Graphene-based disruptive technologies (H2020 Graphene Flagship Core1)
Falko, V. (PI), Baker, J. (CoI), Bussy, C. (CoI), Dryfe, R. (CoI), Geim, A. (CoI), Grigorenko, A. (CoI), Grigorieva, I. (CoI), Kinloch, I. (CoI), Kostarelos, K. (CoI), Novoselov, K. (CoI) & Young, R. (CoI)
1/04/16 → 31/03/18
Project: Research

14 Article
1 Chapter
1 Letter

Correlative radioimaging and mass spectrometry imaging: a powerful combination to study ¹⁴C-graphene oxide in vivo biodistribution
Cazier, H., Malgorn, C., Georgin, D., Fresneau, N., Beau, F., Kostarelos, K., Bussy, C., Campidelli, S., Pinault, M., Mayne-L'hermite, M., Taran, F., Junot, C., Fenaille, F., Sallustrau, A. & Colsch, B., 20 Feb 2023, In: Nanoscale. 15, 11, p. 5510-5518 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxide
Chortarea, S., Kuru, O. C., Netkueakul, W., Pelin, M., Keshavan, S., Song, Z., Ma, B., Gómes, J., Abalos, E. V., Visani de Luna, L. A., Loret, T., Fordham, A., Drummond, M., Kontis, N., Anagnostopoulos, G., Paterakis, G., Cataldi, P., Tubaro, A., Galiotis, C. & Kinloch, I. & 7 others, Fadeel, B., Bussy, C., Kostarelos, K., Buerki-Thurnherr, T., Prato, M., Bianco, A. & Wick, P., 5 Aug 2022, In: Journal of Hazardous Materials. 435, 129053.
Research output: Contribution to journal › Article › peer-review

Open Access
File
198 Downloads (Pure)
Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion
Patil, R., Ray, D., Aswal, V. K., Bussy, C., Bahadur, P. & Tiwari, S. (Corresponding), 19 Jan 2021, In: Langmuir. 37, 2, p. 867–873 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
125 Downloads (Pure)

1 Participating in a conference, workshop, exhibition, performance, inquiry, course etc

9th International Conference on Nanotoxicology
Bussy, C. (Participant)
Sept 2018
Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research

Cite this

Fadeel, B., Bussy, C., Merino, S., Vázquez, E., Flahaut, E., Mouchet, F., Evariste, L., Gauthier, L., Koivisto, A. J., Vogel, U., Martin, C., Delogu, L. G., Bürki-Thurnherr, T., Wick, P., Beloin-Saint-Pierre, D., Hischier, R., Pelin, M., Candotto Carniel, F., Tretiach, M., ... Bianco, A. (2018). Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment. ACS Nano. https://doi.org/10.1021/acsnano.8b04758

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title = "Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment",

abstract = "Graphene and its derivatives are heralded as 'miracle' materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.",

keywords = "Graphene, Safety assessment, Health, Environment effects, 2D materials, Characterisation, Life cycle assessment (LCA), Exposure assessment, Hazard and risk assessment, Nanomaterials, Nanotoxicology",

author = "Bengt Fadeel and Cyrill Bussy and Sonia Merino and Ester V{\'a}zquez and Emmanuel Flahaut and Florence Mouchet and Lauris Evariste and Laury Gauthier and Koivisto, {Antti J} and Ulla Vogel and Cristina Martin and Delogu, {Lucia G} and Tina B{\"u}rki-Thurnherr and Peter Wick and Didier Beloin-Saint-Pierre and Roland Hischier and Marco Pelin and {Candotto Carniel}, Fabio and Mauro Tretiach and Fabrizia Cesca and Fabio Benfenati and Denis Scaini and Laura Ballerini and Kostas Kostarelos and Maurizio Prato and Alberto Bianco",

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Fadeel, B, Bussy, C, Merino, S, Vázquez, E, Flahaut, E, Mouchet, F, Evariste, L, Gauthier, L, Koivisto, AJ, Vogel, U, Martin, C, Delogu, LG, Bürki-Thurnherr, T, Wick, P, Beloin-Saint-Pierre, D, Hischier, R, Pelin, M, Candotto Carniel, F, Tretiach, M, Cesca, F, Benfenati, F, Scaini, D, Ballerini, L, Kostarelos, K, Prato, M & Bianco, A 2018, 'Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment', ACS Nano. https://doi.org/10.1021/acsnano.8b04758

TY - JOUR

T1 - Safety Assessment of Graphene-Based Materials

T2 - Focus on Human Health and the Environment

AU - Fadeel, Bengt

AU - Bussy, Cyrill

AU - Merino, Sonia

AU - Vázquez, Ester

AU - Flahaut, Emmanuel

AU - Mouchet, Florence

AU - Evariste, Lauris

AU - Gauthier, Laury

AU - Koivisto, Antti J

AU - Vogel, Ulla

AU - Martin, Cristina

AU - Delogu, Lucia G

AU - Bürki-Thurnherr, Tina

AU - Wick, Peter

AU - Beloin-Saint-Pierre, Didier

AU - Hischier, Roland

AU - Pelin, Marco

AU - Candotto Carniel, Fabio

AU - Tretiach, Mauro

AU - Cesca, Fabrizia

AU - Benfenati, Fabio

AU - Scaini, Denis

AU - Ballerini, Laura

AU - Kostarelos, Kostas

AU - Prato, Maurizio

AU - Bianco, Alberto

PY - 2018

Y1 - 2018

N2 - Graphene and its derivatives are heralded as 'miracle' materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

AB - Graphene and its derivatives are heralded as 'miracle' materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.

KW - Graphene

KW - Safety assessment

KW - Health

KW - Environment effects

KW - 2D materials

KW - Characterisation

KW - Life cycle assessment (LCA)

KW - Exposure assessment

KW - Hazard and risk assessment

KW - Nanomaterials

KW - Nanotoxicology

U2 - 10.1021/acsnano.8b04758

DO - 10.1021/acsnano.8b04758

M3 - Article

C2 - 30387986

SN - 1936-0851

JO - ACS Nano

JF - ACS Nano

ER -

Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Fingerprint

Projects

Graphene Flagship Core 2 (Division of Pharmacy and Optometry allocation).

Graphene-based disruptive technologies (H2020 Graphene Flagship Core1)

Research output

Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14C-graphene oxide in vivo biodistribution

Hazard Assessment of Abraded Thermoplastic Composites Reinforced with Reduced Graphene Oxide

Adsorption of P103 Nanoaggregates on Graphene Oxide Nanosheets: Role of Electrostatic Forces in Improving Nanosheet Dispersion

Activities

9th International Conference on Nanotoxicology

Cite this

Correlative radioimaging and mass spectrometry imaging: a powerful combination to study ¹⁴C-graphene oxide in vivo biodistribution