Safety Assessment of Graphene‐Based Materials

Bengt Fadeel; James Baker; Laura Ballerini; Cyrill Bussy; Fabio Candotto Carniel; Mauro Tretiach; Marco Pelin; Tina Buerki‐Thurnherr; Tomi Kanerva; José Maria Navas; Ester Vázquez; Virginia Rodriguez Unamuno; Panja Lehtonen; Mar González; Hubert Rauscher; Juan Riego Sintes; Kostas Kostarelos; Alberto Bianco; Maurizio Prato

doi:10.1002/smll.202404570

Safety Assessment of Graphene‐Based Materials

Bengt Fadeel, James Baker, Laura Ballerini, Cyrill Bussy, Fabio Candotto Carniel, Mauro Tretiach, Marco Pelin, Tina Buerki‐Thurnherr, Tomi Kanerva, José Maria Navas, Ester Vázquez, Virginia Rodriguez Unamuno, Panja Lehtonen, Mar González, Hubert Rauscher, Juan Riego Sintes, Kostas Kostarelos, Alberto Bianco, Maurizio Prato

Research output: Contribution to journal › Article › peer-review

12 Downloads (Pure)

Abstract

Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with the emergence of several other atomically thin materials displaying multifunctional properties. The safety assessment of new materials is often something of an afterthought, but in the case of graphene, the initial isolation and characterization of the material was soon followed by the assessment of its potential impact on living systems. The Graphene Flagship project addressed the health and environmental aspects of graphene and other 2D materials, providing an instructive lesson in interdisciplinarity – from materials science to biology. Here, the outcomes of the toxicological and ecotoxicological studies performed on graphene and its derivatives, and the key lessons learned from this decade-long journey, are highlighted.

Original language	English
Article number	e2404570
Journal	Small
Early online date	15 Jan 2025
DOIs	https://doi.org/10.1002/smll.202404570
Publication status	E-pub ahead of print - 15 Jan 2025

Keywords

advanced materials
graphene
safety assessment
test guidelines

Research Beacons, Institutes and Platforms

Advanced materials
National Graphene Institute
Thomas Ashton Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/smll.202404570Licence: CC BY

Small - 2025 - Fadeel - Safety Assessment of GrapheneBased MaterialsFinal published version, 1.03 MBLicence: CC BY

3 Finished

Graphene Flagship Core 3
Kostarelos, K. (PI), Bussy, C. (CoI), Coope, D. (CoI) & Vranic, S. (CoI)
1/04/20 → 30/09/23
Project: Research
Graphene Flagship Core 2 (Division of Pharmacy and Optometry allocation).
Kostarelos, K. (PI) & Bussy, C. (CoI)
1/04/18 → 31/03/20
Project: Research
Graphene-based disruptive technologies (H2020 Graphene Flagship Core1)
Falko, V. (PI), Baker, J. (CoI), Bussy, C. (CoI), Dryfe, R. (CoI), Geim, A. (CoI), Grigorenko, A. (CoI), Grigorieva, I. (CoI), Kinloch, I. (CoI), Kostarelos, K. (CoI), Novoselov, K. (CoI) & Young, R. (CoI)
1/04/16 → 31/03/18
Project: Research

1 Article
1 Review article

Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective
Lin, H., Buerki-Thurnherr, T., Wick, P., Pelin, M., Tubaro, A., Candotto Carniel, F., Tretiach, M., Flahaut, E., Iglesias, D., Vázquez, E., Cellot, G., Ballerini, L., Castagnola, V., Benfenati, F., Armirotti, A., Sallustrau, A., Keck, M., Taran, F., Bussy, C. & Vranic, S. & 11 others, Kostarelos, K., Connolly, M., Navas, J. M., Mouchet, F., Gauthier, L., Baker, J., Suarez-Merino, B., Kanerva, T., Prato, M., Fadeel, B. & Bianco, A., 13 Feb 2024, (E-pub ahead of print) In: ACS Nano.
Research output: Contribution to journal › Review article › peer-review

Open Access
First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses
Andrews, J., Joshi, S., Tzolos, E., Syed, M., Cuthbert, H., Crica, L., Lozano, N., Raftis, J., Bruce, L., Poland, C., Duffin, R., Fokkens, P., Leseman, D., Boere, J., Megson, I., Whitfield, P., Okwelogu, E., Hadjidemetriou, M., Bussy, C. & Cassee, F. & 3 others, Newby, D., Kostarelos, K. & Miller, M., 16 Feb 2024, In: Nature Nanotechnology.
Research output: Contribution to journal › Article › peer-review

Open Access

Cite this

Fadeel, B., Baker, J., Ballerini, L., Bussy, C., Candotto Carniel, F., Tretiach, M., Pelin, M., Buerki‐Thurnherr, T., Kanerva, T., Navas, J. M., Vázquez, E., Rodriguez Unamuno, V., Lehtonen, P., González, M., Rauscher, H., Riego Sintes, J., Kostarelos, K., Bianco, A., & Prato, M. (2025). Safety Assessment of Graphene‐Based Materials. Small, Article e2404570. Advance online publication. https://doi.org/10.1002/smll.202404570

@article{150832e4c4bb49268906d9a21fd8343f,

title = "Safety Assessment of Graphene‐Based Materials",

abstract = "Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with the emergence of several other atomically thin materials displaying multifunctional properties. The safety assessment of new materials is often something of an afterthought, but in the case of graphene, the initial isolation and characterization of the material was soon followed by the assessment of its potential impact on living systems. The Graphene Flagship project addressed the health and environmental aspects of graphene and other 2D materials, providing an instructive lesson in interdisciplinarity – from materials science to biology. Here, the outcomes of the toxicological and ecotoxicological studies performed on graphene and its derivatives, and the key lessons learned from this decade-long journey, are highlighted.",

keywords = "advanced materials, graphene, safety assessment, test guidelines",

author = "Bengt Fadeel and James Baker and Laura Ballerini and Cyrill Bussy and {Candotto Carniel}, Fabio and Mauro Tretiach and Marco Pelin and Tina Buerki‐Thurnherr and Tomi Kanerva and Navas, {Jos{\'e} Maria} and Ester V{\'a}zquez and {Rodriguez Unamuno}, Virginia and Panja Lehtonen and Mar Gonz{\'a}lez and Hubert Rauscher and {Riego Sintes}, Juan and Kostas Kostarelos and Alberto Bianco and Maurizio Prato",

year = "2025",

month = jan,

day = "15",

doi = "10.1002/smll.202404570",

language = "English",

journal = "Small",

issn = "1613-6810",

publisher = "John Wiley & Sons Ltd",

}

TY - JOUR

T1 - Safety Assessment of Graphene‐Based Materials

AU - Fadeel, Bengt

AU - Baker, James

AU - Ballerini, Laura

AU - Bussy, Cyrill

AU - Candotto Carniel, Fabio

AU - Tretiach, Mauro

AU - Pelin, Marco

AU - Buerki‐Thurnherr, Tina

AU - Kanerva, Tomi

AU - Navas, José Maria

AU - Vázquez, Ester

AU - Rodriguez Unamuno, Virginia

AU - Lehtonen, Panja

AU - González, Mar

AU - Rauscher, Hubert

AU - Riego Sintes, Juan

AU - Kostarelos, Kostas

AU - Bianco, Alberto

AU - Prato, Maurizio

PY - 2025/1/15

Y1 - 2025/1/15

N2 - Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with the emergence of several other atomically thin materials displaying multifunctional properties. The safety assessment of new materials is often something of an afterthought, but in the case of graphene, the initial isolation and characterization of the material was soon followed by the assessment of its potential impact on living systems. The Graphene Flagship project addressed the health and environmental aspects of graphene and other 2D materials, providing an instructive lesson in interdisciplinarity – from materials science to biology. Here, the outcomes of the toxicological and ecotoxicological studies performed on graphene and its derivatives, and the key lessons learned from this decade-long journey, are highlighted.

AB - Graphene is the first 2D atomic crystal, and its isolation heralded a new era in materials science with the emergence of several other atomically thin materials displaying multifunctional properties. The safety assessment of new materials is often something of an afterthought, but in the case of graphene, the initial isolation and characterization of the material was soon followed by the assessment of its potential impact on living systems. The Graphene Flagship project addressed the health and environmental aspects of graphene and other 2D materials, providing an instructive lesson in interdisciplinarity – from materials science to biology. Here, the outcomes of the toxicological and ecotoxicological studies performed on graphene and its derivatives, and the key lessons learned from this decade-long journey, are highlighted.

KW - advanced materials

KW - graphene

KW - safety assessment

KW - test guidelines

U2 - 10.1002/smll.202404570

DO - 10.1002/smll.202404570

M3 - Article

SN - 1613-6810

JO - Small

JF - Small

M1 - e2404570

ER -

Safety Assessment of Graphene‐Based Materials

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Fingerprint

Projects

Graphene Flagship Core 3

Graphene Flagship Core 2 (Division of Pharmacy and Optometry allocation).

Graphene-based disruptive technologies (H2020 Graphene Flagship Core1)

Research output

Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Cite this