Abstract
SmI2 is a versatile reagent now widely used in organic chemistry. Despite the wealth of literature on the subject, the mechanisms of some SmI2-mediated reactions are still uncertain and the role of additives and cosolvents is poorly understood. This review covers the use of SmI2-mediated cyclization reactions in natural product synthesis. The use of the full armory of ring-forming reactions conducted by the reagent is outlined. Focus is on the most challenging targets, such as Taxol, gambierol, and diazonamide A.
| Original language | English |
|---|---|
| Pages (from-to) | 3371-3403 |
| Number of pages | 32 |
| Journal | Chemical Reviews |
| Volume | 104 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2004 |
Keywords
- Cyclization (samarium(II)-iodide-mediated cyclizations in natural product synthesis); Natural products Role: SPN (Synthetic preparation), PREP (Preparation) (samarium(II)-iodide-mediated cyclizations in natural product synthesis)