Samarium(II) - mediated linker cleavage - cyclization in fluorous synthesis: Reactions of samarium enolates

Karen M. James; Nigel Willetts; David J. Procter

doi:10.1021/ol800070y

Samarium(II) - mediated linker cleavage - cyclization in fluorous synthesis: Reactions of samarium enolates

Karen M. James, Nigel Willetts, David J. Procter

Research output: Contribution to journal › Article › peer-review

Abstract

Sml2 has been used to cleave a sulfur linker and trigger cyclizations in strategies for the traceless fluorous synthesis of N-heterocycles. The studies give further Insights Into the reactivity of samarium enolates. © 2008 American Chemical Society.

Original language	English
Pages (from-to)	1203-1206
Number of pages	3
Journal	Organic Letters
Volume	10
Issue number	6
DOIs	https://doi.org/10.1021/ol800070y
Publication status	Published - 20 Mar 2008

Keywords

PHASE ORGANIC-SYNTHESIS
CYCLATIVE-CAPTURE STRATEGY
SOLID-PHASE
CARBONYL-COMPOUNDS
N-HETEROCYCLES
IODIDE
REDUCTION
CHEMISTRY
SMI2
SEPARATION

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10.1021/ol800070y

http://pubs.acs.org/doi/pdf/10.1021/ol800070y

CCDC 671492: Experimental Crystal Structure Determination
James, K. M. (Contributor), Willetts, N. (Contributor) & Procter, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2009
DOI: 10.5517/ccqjr10, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccqjr10&sid=DataCite
Dataset

Cite this

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title = "Samarium(II) - mediated linker cleavage - cyclization in fluorous synthesis: Reactions of samarium enolates",

abstract = "Sml2 has been used to cleave a sulfur linker and trigger cyclizations in strategies for the traceless fluorous synthesis of N-heterocycles. The studies give further Insights Into the reactivity of samarium enolates. {\textcopyright} 2008 American Chemical Society.",

keywords = "PHASE ORGANIC-SYNTHESIS, CYCLATIVE-CAPTURE STRATEGY, SOLID-PHASE, CARBONYL-COMPOUNDS, N-HETEROCYCLES, IODIDE, REDUCTION, CHEMISTRY, SMI2, SEPARATION",

author = "James, {Karen M.} and Nigel Willetts and Procter, {David J.}",

note = "James, Karen M. Willetts, Nigel Procter, David J. 46 AMER CHEMICAL SOC WASHINGTON 274VY",

year = "2008",

month = mar,

day = "20",

doi = "10.1021/ol800070y",

language = "English",

volume = "10",

pages = "1203--1206",

journal = "Organic Letters",

issn = "1523-7052",

publisher = "American Chemical Society",

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T1 - Samarium(II) - mediated linker cleavage - cyclization in fluorous synthesis: Reactions of samarium enolates

AU - James, Karen M.

AU - Willetts, Nigel

AU - Procter, David J.

N1 - James, Karen M. Willetts, Nigel Procter, David J. 46 AMER CHEMICAL SOC WASHINGTON 274VY

PY - 2008/3/20

Y1 - 2008/3/20

N2 - Sml2 has been used to cleave a sulfur linker and trigger cyclizations in strategies for the traceless fluorous synthesis of N-heterocycles. The studies give further Insights Into the reactivity of samarium enolates. © 2008 American Chemical Society.

AB - Sml2 has been used to cleave a sulfur linker and trigger cyclizations in strategies for the traceless fluorous synthesis of N-heterocycles. The studies give further Insights Into the reactivity of samarium enolates. © 2008 American Chemical Society.

KW - PHASE ORGANIC-SYNTHESIS

KW - CYCLATIVE-CAPTURE STRATEGY

KW - SOLID-PHASE

KW - CARBONYL-COMPOUNDS

KW - N-HETEROCYCLES

KW - IODIDE

KW - REDUCTION

KW - CHEMISTRY

KW - SMI2

KW - SEPARATION

U2 - 10.1021/ol800070y

DO - 10.1021/ol800070y

M3 - Article

VL - 10

SP - 1203

EP - 1206

JO - Organic Letters

JF - Organic Letters

SN - 1523-7052

IS - 6

ER -

Samarium(II) - mediated linker cleavage - cyclization in fluorous synthesis: Reactions of samarium enolates

Abstract

Keywords

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Datasets

CCDC 671492: Experimental Crystal Structure Determination

Cite this