SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.
- DNA double-strand breaks
- Homologous recombination (HR)
- DNA-end resection