SAMHD1 sheds moonlight on DNA double-strand break repair

Research output: Contribution to journalArticlepeer-review

Abstract

SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.
Original languageEnglish
JournalTrends in genetics : TIG
DOIs
Publication statusPublished - 30 Sept 2017

Keywords

  • SAMHD1
  • DNA double-strand breaks
  • Homologous recombination (HR)
  • DNA-end resection
  • CTIP
  • Cancer

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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