SAMHD1 sheds moonlight on DNA double-strand break repair

Maria Jose Cabello Lobato; Siyue Wang; Christine Schmidt

doi:10.1016/j.tig.2017.09.007

SAMHD1 sheds moonlight on DNA double-strand break repair

Maria Jose Cabello Lobato, Siyue Wang, Christine Schmidt

Research output: Contribution to journal › Article › peer-review

Abstract

SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.

Original language	English
Journal	Trends in genetics : TIG
DOIs	https://doi.org/10.1016/j.tig.2017.09.007
Publication status	Published - 30 Sep 2017

Keywords

SAMHD1
DNA double-strand breaks
Homologous recombination (HR)
DNA-end resection
CTIP
Cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tig.2017.09.007Licence: CC BY

Cite this

@article{978eb2088ced463690a6d76982e53883,

title = "SAMHD1 sheds moonlight on DNA double-strand break repair",

abstract = "SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.",

keywords = "SAMHD1, DNA double-strand breaks , Homologous recombination (HR), DNA-end resection , CTIP , Cancer",

author = "{Cabello Lobato}, {Maria Jose} and Siyue Wang and Christine Schmidt",

year = "2017",

month = sep,

day = "30",

doi = "10.1016/j.tig.2017.09.007",

language = "English",

journal = "Trends in genetics : TIG",

issn = "0168-9525",

publisher = "Elsevier BV",

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TY - JOUR

T1 - SAMHD1 sheds moonlight on DNA double-strand break repair

AU - Cabello Lobato, Maria Jose

AU - Wang, Siyue

AU - Schmidt, Christine

PY - 2017/9/30

Y1 - 2017/9/30

N2 - SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.

AB - SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.

KW - SAMHD1

KW - DNA double-strand breaks

KW - Homologous recombination (HR)

KW - DNA-end resection

KW - CTIP

KW - Cancer

U2 - 10.1016/j.tig.2017.09.007

DO - 10.1016/j.tig.2017.09.007

M3 - Article

JO - Trends in genetics : TIG

JF - Trends in genetics : TIG

SN - 0168-9525

ER -

SAMHD1 sheds moonlight on DNA double-strand break repair

Abstract

Keywords

UN SDGs

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