Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging.

Jonathan M. Behrendt, Jair A. Esquivel Guzman, Laura Purdie, Helen Willcock, John J. Morrison, Andrew B. Foster, Rachel K. O'Reilly, Mark C. McCairn, Michael L. Turner

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    Abstract

    Suzuki cross-coupling polymn. of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilized miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5-50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-IR. The robust nature of the polymn. methodol. allows for rapid assessment of the relationship between polymer compn., chain morphol. and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purifn. step) can be used directly in fluorescence-based intracellular labeling expts. (in HCT116 cells), in which they display low cytotoxicity at biol.-useful concns. [on SciFinder(R)]
    Original languageEnglish
    Pages (from-to)69-77
    Number of pages9
    JournalReactive & Functional Polymers
    Volume107
    DOIs
    Publication statusPublished - 30 Aug 2016

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