Scale-invariant behavior and vascular network formation in normal and tumor tissue

Yuval Gazit, David A. Berk, Michael Leunig, Laurence T. Baxter, Rakesh K. Jain

    Research output: Contribution to journalArticlepeer-review


    Tumor vascular networks look different from normal vascular networks, but the mechanisms underlying these differences are not known. By studying the scale-invariant behavior of normal and tumor vascular networks we show that vascular networks exhibit three classes of fractal behavior. Tumor networks display percolationlike scaling. Normal arteriovenous networks display diffusion-limited scaling, and normal capillary networks are compact structures. The mechanisms responsible for these differences are suggested using a growth model.
    Original languageEnglish
    Pages (from-to)2428-2431
    Number of pages3
    JournalPhysical Review Letters
    Issue number12
    Publication statusPublished - 1995


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