Screening assays for binding antagonists of the AMD-associated variant of factor H (H384).

Simon J. Clark; Anthony J. Day; Paul N. Bishop; Robert B. Sim; Anna M. Blom; Dick Heinegard

Screening assays for binding antagonists of the AMD-associated variant of factor H (H384).

Simon J. Clark (Other), Anthony J. Day (Other), Paul N. Bishop (Other), Robert B. Sim (Other), Anna M. Blom (Other), Dick Heinegard (Other)

Research output: Patent

Abstract

The invention relates to identifying agents which have the ability to preferentially inhibit binding to targets such as heparin of the H384 allotypic variant of human complement Factor H, the allotypic variant associated with age-related macular degeneration (AMD), and the non-disease associated form of the same factor (Y384). The targets of interest show differential binding of the two allotypic variants and antagonists thus identified are of interest in developing treatments for AMD.

Original language	English
Patent number	7829301
Publication status	Published - 11 Sept 2010

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title = "Screening assays for binding antagonists of the AMD-associated variant of factor H (H384).",

abstract = "The invention relates to identifying agents which have the ability to preferentially inhibit binding to targets such as heparin of the H384 allotypic variant of human complement Factor H, the allotypic variant associated with age-related macular degeneration (AMD), and the non-disease associated form of the same factor (Y384). The targets of interest show differential binding of the two allotypic variants and antagonists thus identified are of interest in developing treatments for AMD.",

author = "Clark, {Simon J.} and Day, {Anthony J.} and Bishop, {Paul N.} and Sim, {Robert B.} and Blom, {Anna M.} and Dick Heinegard",

note = "Issuing organisation: USPTOLocation issued: United States; 7829301",

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day = "11",

language = "English",

type = "Patent",

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A2 - Sim, Robert B.

A2 - Blom, Anna M.

A2 - Heinegard, Dick

N1 - Issuing organisation: USPTOLocation issued: United States

PY - 2010/9/11

Y1 - 2010/9/11

N2 - The invention relates to identifying agents which have the ability to preferentially inhibit binding to targets such as heparin of the H384 allotypic variant of human complement Factor H, the allotypic variant associated with age-related macular degeneration (AMD), and the non-disease associated form of the same factor (Y384). The targets of interest show differential binding of the two allotypic variants and antagonists thus identified are of interest in developing treatments for AMD.

AB - The invention relates to identifying agents which have the ability to preferentially inhibit binding to targets such as heparin of the H384 allotypic variant of human complement Factor H, the allotypic variant associated with age-related macular degeneration (AMD), and the non-disease associated form of the same factor (Y384). The targets of interest show differential binding of the two allotypic variants and antagonists thus identified are of interest in developing treatments for AMD.

M3 - Patent

M1 - 7829301

ER -

Screening assays for binding antagonists of the AMD-associated variant of factor H (H384).

Abstract

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