Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study

John G. Hanly, Murray B. Urowitz, Li Su, Caroline Gordon, Sang Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Daniel J. Wallace, Ann E. Clarke, E. M. Ginzler, Joan T. Merrill, David A. Isenberg, Anisur Rahman, M. Petri, Paul R. Fortin, D. D. Gladman, Ian N. Bruce, Kristjan Steinsson, M. A. Dooley, Munther A. KhamashtaGraciela S. Alarcón, Barri J. Fessler, Rosalind Ramsey-Goldman, Susan Manzi, Asad A. Zoma, Gunnar K. Sturfelt, Ola Nived, Cynthia Aranow, Meggan Mackay, Manuel Ramos-Casals, R. F. Van Vollenhoven, Kenneth C. Kalunian, Guillermo Ruiz-Irastorza, Sam Lim, Diane L. Kamen, Christine A. Peschken, Murat Inanc, Chris Theriault, Kara Thompson, Vernon Farewell

    Research output: Contribution to journalArticlepeer-review


    Objective: The aim of this study was to describe the frequency, attribution, outcome and predictors of seizures in systemic lupus erythematosus (SLE). Methods: The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American College of Rheumatology Damage Index (SDI)) and neuropsychiatric events were recorded at enrolment and annually. Lupus anticoagulant, anticardiolipin, anti-β 2glycoprotein-I, antiribosomal P and anti-NR2 glutamate receptor antibodies were measured at enrolment. Physician outcomes of seizures were recorded. Patient outcomes were derived from the SF-36 (36-Item Short Form Health Survey) mental component summary and physical component summary scores. Statistical analyses included Cox and linear regressions. Results: The cohort was 89.4% female with a mean follow-up of 3.5±2.9 years. Of 1631 patients, 75 (4.6%) had ≥1 seizure, the majority around the time of SLE diagnosis. Multivariate analysis indicated a higher risk of seizures with African race/ethnicity (HR (CI): 1.97 (1.07 to 3.63); p=0.03) and lower education status (1.97 (1.21 to 3.19); p
    Original languageEnglish
    Pages (from-to)1502-1509
    Number of pages7
    JournalAnnals of the rheumatic diseases
    Issue number9
    Publication statusPublished - Sep 2012


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