Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance

Michael J. Bottery; A. Jamie Wood; Michael A. Brockhurst

doi:10.1128/AAC.02441-15

Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance

Michael J. Bottery^*, A. Jamie Wood, Michael A. Brockhurst

^*Corresponding author for this work

University of York

Research output: Contribution to journal › Article › peer-review

Abstract

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

Original language	English
Pages (from-to)	2524-2527
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	4
Early online date	25 Mar 2016
DOIs	https://doi.org/10.1128/AAC.02441-15
Publication status	Published - Apr 2016

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10.1128/AAC.02441-15Licence: CC BY

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abstract = "Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.",

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AU - Wood, A. Jamie

AU - Brockhurst, Michael A.

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N2 - Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

AB - Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

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M3 - Article

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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ER -

Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance

Abstract

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