Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance

Research output: Contribution to journalArticlepeer-review

Abstract

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

Original languageEnglish
Pages (from-to)2524-2527
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number4
Early online date25 Mar 2016
DOIs
Publication statusPublished - Apr 2016

Fingerprint

Dive into the research topics of 'Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance'. Together they form a unique fingerprint.

Cite this