TY - JOUR
T1 - Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance
AU - Bottery, Michael J.
AU - Wood, A. Jamie
AU - Brockhurst, Michael A.
PY - 2016/4
Y1 - 2016/4
N2 - Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.
AB - Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.
UR - http://europepmc.org/abstract/med/26787694
UR - https://www.scopus.com/pages/publications/84963752192
U2 - 10.1128/AAC.02441-15
DO - 10.1128/AAC.02441-15
M3 - Article
C2 - 26787694
AN - SCOPUS:84963752192
SN - 0066-4804
VL - 60
SP - 2524
EP - 2527
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -