Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets

Daphne De Launay; Marleen G H Van De Sande; Maria J H De Hair; Aleksander M. Grabiec; Gijs P M Van De Sande; K. Aad Lehmann; Carla A. Wijbrandts; Lisa G M Van Baarsen; Danielle M. Gerlag; Paul P. Tak; Kris A. Reedquist

doi:10.1136/ard.2010.143529

Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets

Daphne De Launay, Marleen G H Van De Sande, Maria J H De Hair, Aleksander M. Grabiec, Gijs P M Van De Sande, K. Aad Lehmann, Carla A. Wijbrandts, Lisa G M Van Baarsen, Danielle M. Gerlag, Paul P. Tak, Kris A. Reedquist

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To investigate the expression and activation of mitogen-activated protein kinases in patients with early arthritis who are disease-modifying antirheumatic drug (DMARD) naïve. Methods: A total of 50 patients with early arthritis who were DMARD naïve (disease duration

Original language	English
Pages (from-to)	415-423
Number of pages	8
Journal	Annals of the rheumatic diseases
Volume	71
Issue number	3
DOIs	https://doi.org/10.1136/ard.2010.143529
Publication status	Published - Mar 2012

Keywords

80 and over
Adult
Aged
Arthritis
Biological Markers
Biological Markers: metabolism
Disease Progression
Early Diagnosis
Enzyme Activation
Enzymologic
Extracellular Signal-Regulated MAP Kinases
Extracellular Signal-Regulated MAP Kinases: geneti
Extracellular Signal-Regulated MAP Kinases: metabo
Female
Gene Expression Profiling
Gene Expression Profiling: methods
Gene Expression Regulation
Humans
JNK Mitogen-Activated Protein Kinases
JNK Mitogen-Activated Protein Kinases: genetics
JNK Mitogen-Activated Protein Kinases: metabolism
Male
Messenger
Messenger: genetics
Middle Aged
Molecular Targeted Therapy
Molecular Targeted Therapy: methods
Phosphorylation
Prognosis
Prospective Studies
RNA
Rheumatoid
Rheumatoid: diagnosis
Rheumatoid: enzymology
Rheumatoid: genetics
Severity of Illness Index
Synovial Membrane
Synovial Membrane: enzymology
Young Adult
p38 Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases: genetics
p38 Mitogen-Activated Protein Kinases: metabolism

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De Launay, D., Van De Sande, M. G. H., De Hair, M. J. H., Grabiec, A. M., Van De Sande, G. P. M., Lehmann, K. A., Wijbrandts, C. A., Van Baarsen, L. G. M., Gerlag, D. M., Tak, P. P., & Reedquist, K. A. (2012). Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Annals of the rheumatic diseases, 71(3), 415-423. https://doi.org/10.1136/ard.2010.143529

De Launay, Daphne ; Van De Sande, Marleen G H ; De Hair, Maria J H et al. / Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. In: Annals of the rheumatic diseases. 2012 ; Vol. 71, No. 3. pp. 415-423.

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title = "Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets",

abstract = "Objectives: To investigate the expression and activation of mitogen-activated protein kinases in patients with early arthritis who are disease-modifying antirheumatic drug (DMARD) na{\"i}ve. Methods: A total of 50 patients with early arthritis who were DMARD na{\"i}ve (disease duration",

keywords = "80 and over, Adult, Aged, Arthritis, Biological Markers, Biological Markers: metabolism, Disease Progression, Early Diagnosis, Enzyme Activation, Enzymologic, Extracellular Signal-Regulated MAP Kinases, Extracellular Signal-Regulated MAP Kinases: geneti, Extracellular Signal-Regulated MAP Kinases: metabo, Female, Gene Expression Profiling, Gene Expression Profiling: methods, Gene Expression Regulation, Humans, JNK Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases: genetics, JNK Mitogen-Activated Protein Kinases: metabolism, Male, Messenger, Messenger: genetics, Middle Aged, Molecular Targeted Therapy, Molecular Targeted Therapy: methods, Phosphorylation, Prognosis, Prospective Studies, RNA, Rheumatoid, Rheumatoid: diagnosis, Rheumatoid: enzymology, Rheumatoid: genetics, Severity of Illness Index, Synovial Membrane, Synovial Membrane: enzymology, Young Adult, p38 Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases: genetics, p38 Mitogen-Activated Protein Kinases: metabolism",

author = "{De Launay}, Daphne and {Van De Sande}, {Marleen G H} and {De Hair}, {Maria J H} and Grabiec, {Aleksander M.} and {Van De Sande}, {Gijs P M} and Lehmann, {K. Aad} and Wijbrandts, {Carla A.} and {Van Baarsen}, {Lisa G M} and Gerlag, {Danielle M.} and Tak, {Paul P.} and Reedquist, {Kris A.}",

year = "2012",

month = mar,

doi = "10.1136/ard.2010.143529",

language = "English",

volume = "71",

pages = "415--423",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "3",

}

De Launay, D, Van De Sande, MGH, De Hair, MJH, Grabiec, AM, Van De Sande, GPM, Lehmann, KA, Wijbrandts, CA, Van Baarsen, LGM, Gerlag, DM, Tak, PP & Reedquist, KA 2012, 'Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets', Annals of the rheumatic diseases, vol. 71, no. 3, pp. 415-423. https://doi.org/10.1136/ard.2010.143529

Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. / De Launay, Daphne; Van De Sande, Marleen G H; De Hair, Maria J H et al.
In: Annals of the rheumatic diseases, Vol. 71, No. 3, 03.2012, p. 415-423.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets

AU - De Launay, Daphne

AU - Van De Sande, Marleen G H

AU - De Hair, Maria J H

AU - Grabiec, Aleksander M.

AU - Van De Sande, Gijs P M

AU - Lehmann, K. Aad

AU - Wijbrandts, Carla A.

AU - Van Baarsen, Lisa G M

AU - Gerlag, Danielle M.

AU - Tak, Paul P.

AU - Reedquist, Kris A.

PY - 2012/3

Y1 - 2012/3

N2 - Objectives: To investigate the expression and activation of mitogen-activated protein kinases in patients with early arthritis who are disease-modifying antirheumatic drug (DMARD) naïve. Methods: A total of 50 patients with early arthritis who were DMARD naïve (disease duration

AB - Objectives: To investigate the expression and activation of mitogen-activated protein kinases in patients with early arthritis who are disease-modifying antirheumatic drug (DMARD) naïve. Methods: A total of 50 patients with early arthritis who were DMARD naïve (disease duration

KW - 80 and over

KW - Adult

KW - Aged

KW - Arthritis

KW - Biological Markers

KW - Biological Markers: metabolism

KW - Disease Progression

KW - Early Diagnosis

KW - Enzyme Activation

KW - Enzymologic

KW - Extracellular Signal-Regulated MAP Kinases

KW - Extracellular Signal-Regulated MAP Kinases: geneti

KW - Extracellular Signal-Regulated MAP Kinases: metabo

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Profiling: methods

KW - Gene Expression Regulation

KW - Humans

KW - JNK Mitogen-Activated Protein Kinases

KW - JNK Mitogen-Activated Protein Kinases: genetics

KW - JNK Mitogen-Activated Protein Kinases: metabolism

KW - Male

KW - Messenger

KW - Messenger: genetics

KW - Middle Aged

KW - Molecular Targeted Therapy

KW - Molecular Targeted Therapy: methods

KW - Phosphorylation

KW - Prognosis

KW - Prospective Studies

KW - RNA

KW - Rheumatoid

KW - Rheumatoid: diagnosis

KW - Rheumatoid: enzymology

KW - Rheumatoid: genetics

KW - Severity of Illness Index

KW - Synovial Membrane

KW - Synovial Membrane: enzymology

KW - Young Adult

KW - p38 Mitogen-Activated Protein Kinases

KW - p38 Mitogen-Activated Protein Kinases: genetics

KW - p38 Mitogen-Activated Protein Kinases: metabolism

U2 - 10.1136/ard.2010.143529

DO - 10.1136/ard.2010.143529

M3 - Article

SN - 0003-4967

VL - 71

SP - 415

EP - 423

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 3

ER -

De Launay D, Van De Sande MGH, De Hair MJH, Grabiec AM, Van De Sande GPM, Lehmann KA et al. Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): A prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets. Annals of the rheumatic diseases. 2012 Mar;71(3):415-423. doi: 10.1136/ard.2010.143529