@article{84d46d469d2147e6a5887e6cb979852b,
title = "Selective recognition of human telomeric G-quadruplex with designed peptide: Via hydrogen bonding followed by base stacking interactions",
abstract = "We described a novel synthetic peptide in which a glutamine residue binds through hydrogen bonding to a guanine-base and a trytophan residue intercalates with K+ resulting in stabilization of a human telomeric G-quadruplex with high selectivity over its complementary c-rich strand and a double-stranded DNA and its complementary C-rich strand. This peptide offers great potential for cancer treatment by inhibiting the telomere extension by telomerase.",
author = "Shikhar Tyagi and Sarika Saxena and Nikita Kundu and Taniya Sharma and Amlan Chakraborty and Sarvpreet Kaur and Daisuke Miyoshi and Jadala Shankaraswamy",
note = "Funding Information: This work was supported by the research grant of {"}Department of Biotechnology (DBT){"}, Govt of India (SAN No. 102/IFD/SAN/864/2018-2019). The timely help from Dr Shrikant Kukreti and Dr Anju from Delhi University in the recording of CD measurements is greatly acknowledged. We also acknowledge Dr Asimul Islam and Dr Anas Shamsi from Jamia Milia Islamia for reevaluating the fluorescence data. Funding Information: This work was supported by the research grant of “Department of Biotechnology (DBT)”, Govt of India (SAN No. 102/IFD/SAN/ 864/2018-2019). The timely help from Dr Shrikant Kukreti and Dr Anju from Delhi University in the recording of CD measurements is greatly acknowledged. We also acknowledge Dr Asimul Islam and Dr Anas Shamsi from Jamia Milia Islamia for reevaluating the uorescence data. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
doi = "10.1039/c9ra08761c",
language = "English",
volume = "9",
pages = "40255--40262",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "69",
}
