Self-association of penicillin V in aqueous solution

Luis M. Varela, Carlos Rega, M. J. Suarez-Filloy, Juan M. Ruso, Gerardo Prieto, David Attwood, Felix Sarmiento, Victor Mosquera

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The self-association of penicillin V in aqueous solution at 298.15 K has been examined by conductivity, density, ultrasound, static light scattering, and microcalorimetry techniques. Two critical concentrations were detected in conductivity, light scattering, and ultrasound data over the concentration range 0-0.35 mol kg-1. Light scattering measurements indicate the formation of trimers at the first critical concentration (0.04 mol kg-1) and subsequent formation of aggregates of aggregation number 12 at the second critical concentration (0.23 mol kg-1). Analysis of the apparent molar volumes and isentropic apparent molar compressibilities has also provided evidence for limited association at concentrations below the first critical concentration. A model of the association process and possible structures of the primary and secondary aggregates have been proposed on the basis of an analysis of the thermodynamics of the self-association.
    Original languageEnglish
    Pages (from-to)6285-6290
    Number of pages5
    JournalLangmuir
    Volume15
    Issue number19
    DOIs
    Publication statusPublished - 14 Sept 1999

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