Self-association of verapamil in aqueous electrolyte solution

Pablo Taboada; Martín Pérez-Rodríguez; David Attwood; Luis M. Varela; Juan M. Ruso; Víctor Mosquera

doi:10.1006/jcis.2001.7738

Self-association of verapamil in aqueous electrolyte solution

Pablo Taboada, Martín Pérez-Rodríguez, David Attwood, Luis M. Varela, Juan M. Ruso, Víctor Mosquera

Research output: Contribution to journal › Article › peer-review

Abstract

The self-association of the amphiphilic drug verapamil hydrochloride in water and in the presence of added electrolyte (0.00.009 mol kg-1 NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques. Aggregation numbers determined by the application of mass action theory to the concentration dependence of 1H NMR chemical shifts were in agreement with values from static light scattering and indicated very limited association (aggregation numbers between 2 and 4). © 2001 Academic Press.

Original language	English
Pages (from-to)	459-464
Number of pages	5
Journal	Journal of Colloid and Interface Science
Volume	241
Issue number	2
DOIs	https://doi.org/10.1006/jcis.2001.7738
Publication status	Published - 15 Sept 2001

Keywords

Critical micelle concentration
Dimers
Nuclear magnetic resonance
Self-association
Verapamil

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10.1006/jcis.2001.7738

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title = "Self-association of verapamil in aqueous electrolyte solution",

abstract = "The self-association of the amphiphilic drug verapamil hydrochloride in water and in the presence of added electrolyte (0.00.009 mol kg-1 NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques. Aggregation numbers determined by the application of mass action theory to the concentration dependence of 1H NMR chemical shifts were in agreement with values from static light scattering and indicated very limited association (aggregation numbers between 2 and 4). {\textcopyright} 2001 Academic Press.",

keywords = "Critical micelle concentration, Dimers, Nuclear magnetic resonance, Self-association, Verapamil",

author = "Pablo Taboada and Mart{\'i}n P{\'e}rez-Rodr{\'i}guez and David Attwood and Varela, {Luis M.} and Ruso, {Juan M.} and V{\'i}ctor Mosquera",

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doi = "10.1006/jcis.2001.7738",

language = "English",

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T1 - Self-association of verapamil in aqueous electrolyte solution

AU - Taboada, Pablo

AU - Pérez-Rodríguez, Martín

AU - Attwood, David

AU - Varela, Luis M.

AU - Ruso, Juan M.

AU - Mosquera, Víctor

PY - 2001/9/15

Y1 - 2001/9/15

N2 - The self-association of the amphiphilic drug verapamil hydrochloride in water and in the presence of added electrolyte (0.00.009 mol kg-1 NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques. Aggregation numbers determined by the application of mass action theory to the concentration dependence of 1H NMR chemical shifts were in agreement with values from static light scattering and indicated very limited association (aggregation numbers between 2 and 4). © 2001 Academic Press.

AB - The self-association of the amphiphilic drug verapamil hydrochloride in water and in the presence of added electrolyte (0.00.009 mol kg-1 NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques. Aggregation numbers determined by the application of mass action theory to the concentration dependence of 1H NMR chemical shifts were in agreement with values from static light scattering and indicated very limited association (aggregation numbers between 2 and 4). © 2001 Academic Press.

KW - Critical micelle concentration

KW - Dimers

KW - Nuclear magnetic resonance

KW - Self-association

KW - Verapamil

U2 - 10.1006/jcis.2001.7738

DO - 10.1006/jcis.2001.7738

M3 - Article

SN - 0021-9797

VL - 241

SP - 459

EP - 464

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

IS - 2

ER -

Self-association of verapamil in aqueous electrolyte solution

Abstract

Keywords

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