Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease

Fiona Blackhall; AD Atkinson; MB Maaya; WD Ryder; G Horne; DR Brison; BA Lieberman; JA Radford

doi:10.1038%2Fsj.bjc.6600483

Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease

Fiona Blackhall, AD Atkinson, MB Maaya, WD Ryder, G Horne, DR Brison, BA Lieberman, JA Radford

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.

Original language	English
Pages (from-to)	381-384
Number of pages	4
Journal	British Journal of Cancer
Volume	87
DOIs	https://doi.org/10.1038%2Fsj.bjc.6600483
Publication status	Published - 12 Aug 2002

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title = "Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease",

abstract = "Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.",

author = "Fiona Blackhall and AD Atkinson and MB Maaya and WD Ryder and G Horne and DR Brison and BA Lieberman and JA Radford",

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TY - JOUR

T1 - Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease

AU - Blackhall, Fiona

AU - Atkinson, AD

AU - Maaya, MB

AU - Ryder, WD

AU - Horne, G

AU - Brison, DR

AU - Lieberman, BA

AU - Radford, JA

PY - 2002/8/12

Y1 - 2002/8/12

N2 - Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.

AB - Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.

U2 - 10.1038%2Fsj.bjc.6600483

DO - 10.1038%2Fsj.bjc.6600483

M3 - Article

SN - 0007-0920

VL - 87

SP - 381

EP - 384

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease

Abstract

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