Senescence in adipose-derived stem cells and its implications in nerve regeneration.

Cristina Mantovani, Giorgio Terenghi, Valerio Magnaghi

    Research output: Contribution to journalArticlepeer-review


    Adult mesenchymal stem cells, specifically adipose-derived stem cells have self-renewal and multiple differentiation potentials and have shown to be the ideal candidate for therapeutic applications in regenerative medicine, particularly in peripheral nerve regeneration. Adipose-derived stem cells are easily harvested, although they may show the effects of aging, hence their potential in nerve repair may be limited by cellular senescence or donor age. Cellular senescence is a complex process whereby stem cells grow old as consequence of intrinsic events (e.g., DNA damage) or environmental cues (e.g., stressful stimuli or diseases), which determine a permanent growth arrest. Several mechanisms are implicated in stem cell senescence, although no one is exclusive of the others. In this review we report some of the most important factors modulating the senescence process, which can influence adipose-derived stem cell morphology and function, and compromise their clinical application for peripheral nerve regenerative cell therapy.
    Original languageEnglish
    JournalNeural Regeneration Research
    Issue number1
    Publication statusPublished - 1 Jan 2014


    • DNA damage
    • Sirtuins
    • adipose-derived stem cell
    • aging
    • mitochondria
    • p38
    • p53
    • peripheral nervous system


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