Sensitivity to Fas-mediated apoptosis is determined below receptor level in human vascular smooth muscle cells

Shiu Wan Chan, Laszlo Hegyi, Stephen Scott, Nathaniel R B Cary, Peter L. Weissberg, Martin R. Bennett

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Despite Fas expression, many cells resist Fas-induced apoptosis. Although differences in surface Fas expression can explain Fas resistance, multiple proteins below receptor level also inhibit Fas-induced apoptosis. To examine the mechanism of Fas resistance, we studied Fas-induced apoptosis in human medial vascular smooth muscle cells (VSMCs) from healthy coronary arteries. VSMCs showed marked heterogeneity to Fas-induced apoptosis, exhibiting both Fas-resistant (98.1 ± 2.3% viable, n = 4, P = NS) and Fas- sensitive (31.3 ± 2.6% viable, n = 3, P
    Original languageEnglish
    Pages (from-to)1038-1046
    Number of pages8
    JournalCirculation research
    Volume86
    Issue number10
    Publication statusPublished - 26 May 2000

    Keywords

    • Apoptosis
    • Remodeling
    • Vascular smooth muscle cell

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